Typical Testing Data/Standard Curve (for reference only)
Rat HTR2C/5-Hydroxytryptamine Receptor 2C ELISA Kit | HTR2C elisa kit
Rat HTR2C/5-Hydroxytryptamine Receptor 2C ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]
Uniprot Description
5-HT(2C): a G-protein coupled receptor. One of several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Mediates its action by activating a phosphatidylinositol-calcium second messenger system.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: Xq34
Cellular Component: cell surface; external side of plasma membrane; integral component of plasma membrane; intracellular; plasma membrane
Molecular Function: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; drug binding; G-protein coupled serotonin receptor activity; Gq/11-coupled serotonin receptor activity; neurotransmitter receptor activity; protein binding; serotonin binding
Biological Process: behavioral fear response; behavioral response to nicotine; cellular calcium ion homeostasis; cGMP biosynthetic process; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G-protein coupled serotonin receptor signaling pathway; G-protein signaling, phospholipase D activating pathway; inositol phosphate-mediated signaling; locomotory behavior; negative regulation of dopamine metabolic process; negative regulation of locomotion; organ regeneration; phospholipase C-activating G-protein coupled receptor signaling pathway; phospholipase C-activating serotonin receptor signaling pathway; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of ERK1 and ERK2 cascade; positive regulation of fat cell differentiation; positive regulation of gamma-aminobutyric acid secretion; positive regulation of phosphatidylinositol biosynthetic process; positive regulation of vasoconstriction; regulation of appetite; regulation of corticotropin-releasing hormone secretion; regulation of neurological process; regulation of sensory perception of pain; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway
Research Articles on HTR2C
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Product Notes
The Rat HTR2C htr2c (Catalog #AAA2889802) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2889802 ELISA Kit recognizes Rat HTR2C. It is sometimes possible for the material contained within the vial of "HTR2C/5-Hydroxytryptamine Receptor 2C, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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