Rat Hepcidin (Hepc) ELISA Kit | Hepc elisa kit
Rat Hepcidin (Hepc) Mini Samples ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
may play a role in the regulation of iron metabolism [RGD, Feb 2006]
Uniprot Description
HAMP: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B); also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy. Belongs to the hepcidin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: apical cortex; cytoplasm; extracellular region; extracellular space; nucleus
Molecular Function: copper ion binding; hormone activity; receptor binding
Biological Process: acute-phase response; aging; cellular iron ion homeostasis; defense response to bacterium; defense response to fungus; iron ion homeostasis; JAK-STAT cascade; membrane protein proteolysis; myeloid cell homeostasis; negative regulation of bone resorption; negative regulation of inflammatory response; negative regulation of ion transmembrane transporter activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of macrophage activation; positive regulation of receptor internalization; positive regulation of transcription from RNA polymerase II promoter; response to ethanol; response to iron ion; response to vitamin A; response to zinc ion
Research Articles on Hepc
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Product Notes
The Rat Hepc hamp (Catalog #AAA2087941) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2087941 ELISA Kit recognizes Rat Hepc. It is sometimes possible for the material contained within the vial of "Hepcidin (Hepc), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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