Rat Epidermal Growth Factor Receptor 2 (EGFR2) ELISA Kit | EGFR2 elisa kit

Rat Epidermal Growth Factor Receptor 2 (EGFR2) ELISA Kit

Cat. Num. AAA452401

• Reactivity: Rat
• Synonyms: Epidermal Growth Factor Receptor 2 (EGFR2); Rat Epidermal Growth Factor Receptor 2 (EGFR2) ELISA Kit; CD340; ErbB2; HER-2/neu; HER2; NEU; MLN 19; NGL; TKR1; p185; V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2; Neuro/Glioblastoma Derived Oncogene Homolog; EGFR2 elisa kit

• Reactivity: Rat
• Sequence Length: 1257

• Samples: Serum, plasma and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.625-40ng/mL
• Sensitivity: 0.221ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 3915663
• NCBI GeneID: 24337
• UniProt Accession #: P06494; Q6P732
• Molecular Weight: 138,832 Da
• NCBI Official Full Name: Receptor tyrosine-protein kinase erbB-2
• NCBI Official Synonym Full Names: erb-b2 receptor tyrosine kinase 2
• NCBI Official Symbol: Erbb2
• NCBI Protein Information: receptor tyrosine-protein kinase erbB-2
• UniProt Protein Name: Receptor tyrosine-protein kinase erbB-2
• UniProt Gene Name: Erbb2
• UniProt Synonym Gene Names: Neu

NCBI Description

may play a role in cell proliferation and differentiation [RGD, Feb 2006]

Uniprot Description

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (). Interacts (preferentially with the tyrosine phosphorylated form) with CPNE3; this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner ().