RAS guanyl-releasing protein 2 (RASGRP2) Recombinant Protein | RASGRP2 recombinant protein

Recombinant Human RAS guanyl-releasing protein 2 (RASGRP2)

Cat. Num. AAA1477472

• Gene Names: RASGRP2; CDC25L; CALDAG-GEFI
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: RAS guanyl-releasing protein 2 (RASGRP2); Recombinant Human RAS guanyl-releasing protein 2 (RASGRP2); RASGRP2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-609, Full length protein
• Sequence: MAGTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMVSYFLRSSSVLGGRMGFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSLPRPGRRGSRPPEIREEEVQTVEDGVFDIHL
• Sequence Length: 609

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for RASGRP2 recombinant protein

This protein is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol
phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1
RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 149158727
• NCBI GeneID: 10235
• NCBI Accession #: NP_001092140.1
• NCBI GenBank Nucleotide #: NM_001098670.1
• UniProt Accession #: Q7LDG7; O00538; Q9UL65; A6NDC7
• Molecular Weight: 69,320 Da
• NCBI Official Full Name: RAS guanyl-releasing protein 2 isoform a
• NCBI Official Synonym Full Names: RAS guanyl releasing protein 2
• NCBI Official Symbol: RASGRP2
• NCBI Official Synonym Symbols: CDC25L; CALDAG-GEFI
• NCBI Protein Information: RAS guanyl-releasing protein 2
• UniProt Protein Name: RAS guanyl-releasing protein 2
• Protein Family: RAS guanyl-releasing protein
• UniProt Gene Name: RASGRP2
• UniProt Synonym Gene Names: CDC25L; MCG7; CalDAG-GEFI; hCDC25L

NCBI Description

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Uniprot Description

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.