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Western Blot (WB) (mouse kidney tissue were subjected to SDS PAGE followed by western blot with MBS7603365 (RASGRP2 antibody) at dilution of 1:300)

Rabbit anti-Human, Mouse RASGRP2 Polyclonal Antibody | anti-RASGRP2 antibody

RASGRP2 Rabbit Polyclonal

Gene Names
RASGRP2; CDC25L; CALDAG-GEFI
Reactivity
Human, Mouse
Applications
ELISA, Western Blot
Purity
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Synonyms
RASGRP2; Polyclonal Antibody; RASGRP2 Rabbit Polyclonal; anti-RASGRP2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Form/Format
Liquid
Sequence Length
609
Applicable Applications for anti-RASGRP2 antibody
ELISA (EIA), Western Blot (WB)
Immunogen
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse kidney tissue were subjected to SDS PAGE followed by western blot with MBS7603365 (RASGRP2 antibody) at dilution of 1:300)

Western Blot (WB) (mouse kidney tissue were subjected to SDS PAGE followed by western blot with MBS7603365 (RASGRP2 antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
69,320 Da
NCBI Official Full Name
RAS guanyl-releasing protein 2
NCBI Official Synonym Full Names
RAS guanyl releasing protein 2
NCBI Official Symbol
RASGRP2
NCBI Official Synonym Symbols
CDC25L; CALDAG-GEFI
NCBI Protein Information
RAS guanyl-releasing protein 2
UniProt Protein Name
RAS guanyl-releasing protein 2
UniProt Gene Name
RASGRP2
UniProt Synonym Gene Names
CDC25L; MCG7; CalDAG-GEFI; hCDC25L
UniProt Entry Name
GRP2_HUMAN

NCBI Description

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Uniprot Description

RASGRP2 iso2: Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. Belongs to the RASGRP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Ras

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytosol; plasma membrane

Molecular Function: calcium ion binding; guanyl-nucleotide exchange factor activity; lipid binding

Biological Process: positive regulation of GTPase activity; signal transduction

Disease: Bleeding Disorder, Platelet-type, 18

Research Articles on RASGRP2

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Product Notes

The RASGRP2 rasgrp2 (Catalog #AAA7603365) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RASGRP2 Rabbit Polyclonal reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's RASGRP2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the RASGRP2 rasgrp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RASGRP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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