Chemerin/RARRES2 Recombinant Protein | RARRES2 recombinant protein

Chemerin/RARRES2 Protein, Mouse, Recombinant (hFc Tag)

Cat. Num. AAA8122475

• Gene Names: Rarres2; AI303516; 0610007L05Rik
• Purity: >90% as determined by SDS-PAGE
• Synonyms: Chemerin/RARRES2; Chemerin/RARRES2 Protein; Mouse; Recombinant (hFc Tag); Mouse RARRES2/TIG2 Protein (Fc Tag); 0610007L05Rik Protein; AI303516 Protein; retinoic acid receptor responder (tazarotene induced) 2; RARRES2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Ser156

• Species: Mouse
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Thr 17
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the mouse Rarres2 (NP_082128.1)(Met1-Ser156) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for RARRES2 recombinant protein

Background: Retinoic acid receptor responder protein 2 (RARRES2) is a small secreted protein involved in multiple cancers, including adrenocortical carcinoma (ACC). Serum RARRES2 may be used as a novel prognostic marker for ACC. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally downregulated in multiple cancer types. Previous studies suggested that it can serve as an immune-dependent tumor suppressor by acting as a chemoattractant to recruit anticancer immune cells expressing its receptor, the chemerin chemokine receptor 1 (CMKLR1), to sites of tumor. Mechanistically, RARRES2 overexpression in ACC cells inhibited Wnt/beta-catenin pathway activity by promoting beta-catenin phosphorylation and degradation, it also inhibited the phosphorylation of p38 mitogen-activated protein kinase. Thus RARRES2 is a novel tumor suppressor for ACC, which can function through an immune-independent mechanism.

NCBI and Uniprot Product Information

• NCBI GI #: 21313658
• NCBI GeneID: 71660
• NCBI Accession #: NP_082128.1
• NCBI GenBank Nucleotide #: NM_027852.3
• UniProt Accession #: Q9DD06; Q8CHU8
• Molecular Weight: 18,350 Da
• NCBI Official Full Name: retinoic acid receptor responder protein 2 isoform 2 preproprotein
• NCBI Official Synonym Full Names: retinoic acid receptor responder (tazarotene induced) 2
• NCBI Official Symbol: Rarres2
• NCBI Official Synonym Symbols: AI303516; 0610007L05Rik
• NCBI Protein Information: retinoic acid receptor responder protein 2
• UniProt Protein Name: Retinoic acid receptor responder protein 2
• Protein Family: Retinoic acid receptor responder protein
• UniProt Gene Name: Rarres2
• UniProt Entry Name: RARR2_MOUSE

Uniprot Description

RARRES2: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular matrix; extracellular region

Molecular Function: protein binding; receptor binding

Biological Process: positive regulation of chemotaxis; brown fat cell differentiation; positive regulation of fat cell differentiation; defense response; positive regulation of protein amino acid phosphorylation; inflammatory response; chemotaxis; retinoid metabolic process; cell differentiation; embryonic gut development; regulation of lipid catabolic process