5HT1A positive control

5HT1A Receptor Positive Control

Cat. Num. AAA542494

• Gene Names: Htr1a; 5HT1A; RAT5HT1A
• Applications: Western Blot
• Synonyms: 5HT1A; 5HT1A Receptor Positive Control; ADRBRL1; G 21; Gpcr18; Guanine nucleotide binding regulatory protein-coupled receptor; HTR1A; PFMCD antibod; 5HT1A positive control

• Host: Rabbit
• Form/Format: Western Blot Positive Control
• Sequence Length: 422

• Applicable Applications for 5HT1A positive control: Western Blot (WB)
• Application Notes: Western Blot: 1:2,500-1:5,000
• Immunogen: Purified Protein
• Expression: Lymph nodes, thymus, spleen, activated T-cells
• Molecular Function: serotonin receptor activity
• Structure: Heterodimer
• Subcellular Location: Cell membrane; Multi-pass protein
• Preparation and Storage: -20 degree C for long term storage

Related Product Information for 5HT1A positive control

Western Blot Positive Control 5 Hydroxytryptamine 1A receptor
G-protein coupled receptor for serotonin (5-hydroxytryptamine). Functions as a receptor for various drugs which cause conformational change upon ligand binding that triggers signaling via guanine nucleo-tide binding proteins and modulation of down-stream effectors like adenylate cyclase. Inhibits adenylate cyclase activity and activates phosphatidylinositol-calcium second messenger system that regulates release of intracellular Calcium ions.

NCBI and Uniprot Product Information

• NCBI GI #: 6981054
• NCBI GeneID: 24473
• NCBI Accession #: NP_036717
• NCBI GenBank Nucleotide #: NM_012585.1
• UniProt Accession #: P19327
• Molecular Weight: 46,429 Da
• NCBI Official Full Name: 5-hydroxytryptamine receptor 1A
• NCBI Official Synonym Full Names: 5-hydroxytryptamine receptor 1A
• NCBI Official Symbol: Htr1a
• NCBI Official Synonym Symbols: 5HT1A; RAT5HT1A
• NCBI Protein Information: 5-hydroxytryptamine receptor 1A
• UniProt Protein Name: 5-hydroxytryptamine receptor 1A
• UniProt Gene Name: Htr1a
• UniProt Synonym Gene Names: 5ht1a; 5-HT-1A; 5-HT1A
• UniProt Entry Name: 5HT1A_RAT

NCBI Description

regulates AMPA receptor channels in the prefrontal cortex; regulation is mediated via inhibition of Ca2+/calmodulin-dependent kinase II [RGD, Feb 2006]

Uniprot Description

5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Cellular Component: axon hillock; cell soma; integral to plasma membrane; membrane

Molecular Function: drug binding; G-protein alpha-subunit binding; protein binding; serotonin binding; serotonin receptor activity

Biological Process: behavioral fear response; cell proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of microtubule depolymerization; regulation of behavior; regulation of dopamine metabolic process; regulation of hormone secretion; regulation of serotonin secretion; serotonin metabolic process; serotonin receptor signaling pathway; serotonin receptor, adenylate cyclase inhibiting pathway; vasoconstriction