Rabbit anti-Human, rat 5-HT1A Polyclonal Antibody | anti-HTR1A antibody

5-HT1A Antibody

Cat. Num. AAA9207248

• Gene Names: HTR1A; G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1
• Reactivity: Human, rat
• Applications: Western Blot, ELISA
• Purity: Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: 5-HT1A; Polyclonal Antibody; 5-HT1A Antibody; 5-hydroxytryptamine receptor 1A; 5-HT-1A; G-21; Serotonin receptor 1A; HTR1A; ADRB2RL1; ADRBRL1; anti-HTR1A antibody

• Host: Rabbit
• Reactivity: Human, rat
• Clonality: Polyclonal
• Purity/Purification: Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
• Concentration: 1mg/ml (varies by lot)
• Sequence Positions: 291-350
• Sequence Length: 422

• Applicable Applications for anti-HTR1A antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~ 1:1000
• Antigen Type: synthetic peptide
• Antigen Source: KLH conjugated synthetic peptide derived from human 5-HT1A
• Preparation and Storage: Store at -20 degree C.Stable for 12 months from date of receipt

Western Blot (WB)

(Anti-5-HT1A Antibody at 1:1000 dilution + human brain lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilutionPredicted band size : 46 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-HTR1A antibody

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Product Categories/Family for anti-HTR1A antibody

Cancer; Metabolism; Signal Transduction

References

Kobilka B.K.,et al.Nature 329:75-79(1987).
Saltzman A.G.,et al.Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases.
Levy F.O.,et al.Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases.
Kitano T.,et al.Mol. Biol. Evol. 21:936-944(2004).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.

NCBI and Uniprot Product Information

• NCBI GI #: 55956923
• NCBI GeneID: 3350
• NCBI Accession #: NP_000515.2
• NCBI GenBank Nucleotide #: NM_000524.3
• UniProt Accession #: P08908; Q6LAE7
• Molecular Weight: 46107
• NCBI Official Full Name: 5-hydroxytryptamine receptor 1A
• NCBI Official Synonym Full Names: 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
• NCBI Official Symbol: HTR1A
• NCBI Official Synonym Symbols: G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1
• NCBI Protein Information: 5-hydroxytryptamine receptor 1A
• UniProt Protein Name: 5-hydroxytryptamine receptor 1A
• Protein Family: 5-hydroxytryptamine receptor
• UniProt Gene Name: HTR1A
• UniProt Synonym Gene Names: ADRB2RL1; ADRBRL1; 5-HT-1A; 5-HT1A
• UniProt Entry Name: 5HT1A_HUMAN

NCBI Description

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

Uniprot Description

5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q11.2-q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; serotonin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; vasoconstriction; behavioral fear response; serotonin receptor, adenylate cyclase inhibiting pathway; regulation of serotonin secretion; regulation of dopamine metabolic process; positive regulation of cell proliferation; regulation of hormone secretion; serotonin metabolic process; serotonin receptor signaling pathway; regulation of behavior

Disease: Periodic Fever, Menstrual Cycle-dependent