NHE6 / Sodium/hydrogen exchanger 6 Peptide | NHE6 peptide

NHE6 / Sodium/hydrogen exchanger 6

Cat. Num. AAA396417

• Gene Names: SLC9A6; MRSA; NHE6
• Reactivity: Human
• Applications: Western Blot
• Synonyms: NHE6 / Sodium/hydrogen exchanger 6; Sodium/hydrogen exchanger 6; NHE6; Solute carrier family 9 member 6; SL9A6; NHE6 peptide

• Host: Rabbit
• Reactivity: Human
• Form/Format: Provided as solution in phosphate buffered saline with 0.08% sodium azide
• Sequence Length: 701

• Applicable Applications for NHE6 peptide: Western Blot (WB)
• Immunogen: Synthetic peptide derived from human NHE6 protein
• Positive Control: Ubiquitous; most abundant in mitochondrion-rich tissues such as brain, skeletal muscle and heart.
• Preparation and Storage: Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Related Product Information for NHE6 peptide

Electroneutral exchange of protons for Na(+) and K(+) across the mitochondrial inner membrane. Contributes to organellar volume and calcium homeostasis.

Product Categories/Family for NHE6 peptide

Blocking Peptide

NCBI and Uniprot Product Information

• NCBI GI #: 110227626
• NCBI GeneID: 10479
• NCBI Accession #: NP_001036002.1
• NCBI GenBank Nucleotide #: NM_001042537.1
• UniProt Accession #: Q92581; Q3ZCW7; Q5JPP8; Q5JPP9; Q86VS0; A6NIQ9; A8K160; B4DU30; B7ZAE0
• Molecular Weight: 74 kDa
• NCBI Official Full Name: sodium/hydrogen exchanger 6 isoform a
• NCBI Official Synonym Full Names: solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
• NCBI Official Symbol: SLC9A6
• NCBI Official Synonym Symbols: MRSA; NHE6
• NCBI Protein Information: sodium/hydrogen exchanger 6; Na(+)/H(+) exchanger 6; solute carrier family 9 (sodium/hydrogen exchanger), member 6
• UniProt Protein Name: Sodium/hydrogen exchanger 6
• UniProt Gene Name: SLC9A6
• UniProt Synonym Gene Names: KIAA0267; NHE6; NHE-6
• UniProt Entry Name: SL9A6_HUMAN

NCBI Description

This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Uniprot Description

Function: Electroneutral exchange of protons for Na+ and K+ across the early and recycling endosome membranes. Contributes to calcium homeostasis.

Subcellular location: Endosome membrane; Multi-pass membrane protein. Note: Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane. Ref.6

Tissue specificity: Ubiquitous; but is most abundant in mitochondrion-rich tissues such as brain, skeletal muscle and heart.

Involvement in disease: Mental retardation, X-linked, syndromic, Christianson type (MRXSCH) [MIM:300243]: A syndrome characterized by profound mental retardation, epilepsy, ataxia, and microcephaly. It shows phenotypic overlap with Angelman syndrome.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Sequence similarities: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]

Caution: Was originally (Ref.1) identified as a mitochondrial inner membrane protein, but was later shown to be localized in early and recycling endosomes and not mitochondria (Ref.6).