Western Blot (WB)
(Western blot analysis of NHE6 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates.)
Rabbit NHE6 Polyclonal Antibody | anti-SLC9A6 antibody
Anti-NHE6 Antibody
Western Blot (WB)
(Western blot analysis of NHE6 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of NHE6 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Uniprot Description
NHE6: Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis. Defects in SLC9A6 are the cause of mental retardation syndromic X-linked Christianson type (MRXSC); also known as MRXS-Christianson or X-linked Angelman-like syndrome. The phenotype is characterized by profound mental retardation, epilepsy, ataxia, and microcephaly, and showed phenotypic overlap with Angelman syndrome. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq26.3
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; mitochondrion; recycling endosome membrane; early endosome membrane; dendrite; late endosome; plasma membrane; integral to membrane; synapse; cytoplasmic vesicle; nerve terminal
Molecular Function: sodium:hydrogen antiporter activity
Biological Process: transport; axon extension; brain-derived neurotrophic factor receptor signaling pathway; synapse organization and biogenesis; regulation of pH; ion transport; regulation of nerve growth factor receptor signaling pathway; transmembrane transport; neurite morphogenesis
Disease: Mental Retardation, X-linked, Syndromic, Christianson Type
Research Articles on SLC9A6
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Product Notes
The SLC9A6 slc9a6 (Catalog #AAA821676) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-NHE6 Antibody reacts with Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's NHE6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1/500 - 1/1000). Researchers should empirically determine the suitability of the SLC9A6 slc9a6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NHE6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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