Testing Data
(Western blot analysis of extracts of PC-3cell lines, using TIMP3 antibody.)
Rabbit TIMP3 Antibody | anti-TIMP3 antibody
TIMP3 Antibody
Gene Names
TIMP3; SFD; K222; K222TA2; HSMRK222
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
Affinity purification
Synonyms
TIMP3; TIMP3 Antibody; HSMRK222; K222; K222TA2; SFD; anti-TIMP3 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Isotype
IgG
Purity/Purification
Affinity purification
Sequence Length
211
Applicable Applications for anti-TIMP3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IHC: 1:50-1:200
Immunogen
Recombinant protein of human TIMP3
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
Testing Data
(Western blot analysis of extracts of PC-3cell lines, using TIMP3 antibody.)
Testing Data
(Western blot analysis of extracts of PC-3cell lines, using TIMP3 antibody.)
Related Product Information for anti-TIMP3 antibody
TIMPs are members of the family of tissue inhibitor of matrix metalloproteinases (MMPs) that includes TIMP1, TIMP2, TIMP3, and TIMP4. The main function of TIMPs is their inhibitory effect on MMPs. TIMPs irreversibly inactivate MMPs by direct binding to their catalytic zinc cofactor and resultant inhibition of proteinase function (1, 2). In addition to MMP inhibition, TIMPs have also been shown to interact with various membrane receptors on the cell surface. Some of these interactions include: TIMP1 with CD63, TIMP2 with alpha3beta1 integrin, and TIMP3 with VEGFR2, all of which result in distinct cellular effects (3). TIMPs are involved in a wide variety of biological functions, such as tumor angiogenesis and progression (4, 5), wound healing, and vascular remodeling (6, 7). Mutations in TIMP3 are associated with Sorsby's fundus dystrophy (8, 9).
Product Categories/Family for anti-TIMP3 antibody
References
1. Nagase, H. et al. (2006) Cardiovasc Res 69, 562-73. 2. Visse, R. and Nagase, H. (2003) Circ Res 92, 827-39. 3. Stetler-Stevenson, W.G. (2008) Sci Signal 1, re6. 4. Noel, A. et al. (2004) J Clin Pathol 57, 577-84. 5. Hojilla, C.V. et al. (2003) Br J Cancer 89, 1817-21. 6. Gill, S.E. and Parks, W.C. (2008) Int J Biochem Cell Biol 40, 1334-47. 7. Raffetto, J.D. and Khalil, R.A. (2008) Biochem Pharmacol 75, 346-59. 8. Weber, B.H. et al. (1994) Nat Genet 8, 352-6. 9. Yeow, K.M. et al. (2002) Matrix Biol 21, 75-88.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
24kDa
NCBI Official Full Name
metalloproteinase inhibitor 3
NCBI Official Synonym Full Names
TIMP metallopeptidase inhibitor 3
NCBI Official Symbol
TIMP3
NCBI Official Synonym Symbols
SFD; K222; K222TA2; HSMRK222
NCBI Protein Information
metalloproteinase inhibitor 3
UniProt Protein Name
Metalloproteinase inhibitor 3
Protein Family
UniProt Gene Name
TIMP3
UniProt Synonym Gene Names
TIMP-3
NCBI Description
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]
Uniprot Description
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Research Articles on TIMP3
Similar Products
Product Notes
The TIMP3 timp3 (Catalog #AAA8502051) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TIMP3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TIMP3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the TIMP3 timp3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIMP3, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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