Western Blot (WB)
(Western Blot analysis of Mouse lung tissue, using HOPX Polyclonal Antibody at dilution of 1:300)
Rabbit HOPX Antibody | anti-HOPX antibody
HOPX Antibody
IHC: 1:50-1:500
Western Blot (WB)
(Western Blot analysis of Mouse lung tissue, using HOPX Polyclonal Antibody at dilution of 1:300)
Western Blot (WB)
(Western Blot analysis of Mouse lung tissue, using HOPX Polyclonal Antibody at dilution of 1:300)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using HOPX Polyclonal Antibody at dilution of 1:200)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using HOPX Polyclonal Antibody at dilution of 1:200)
NCBI and Uniprot Product Information
Observed MW: 8-12kDa
NCBI Description
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]
Uniprot Description
HOPX: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Oncoprotein
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: nucleus
Molecular Function: DNA binding
Biological Process: negative regulation of cell differentiation; transcription, DNA-dependent; positive regulation of skeletal muscle regeneration; regulation of protein binding; heart development; histone deacetylation; positive regulation of striated muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; alveolus development; regulation of heart contraction; trophectodermal cell differentiation
Research Articles on HOPX
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Product Notes
The HOPX hopx (Catalog #AAA2520822) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HOPX Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HOPX can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:200-1:1000 IHC: 1:50-1:500. Researchers should empirically determine the suitability of the HOPX hopx for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HOPX, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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