GSN Antibody | anti-GSN antibody

GSN Antibody

Cat. Num. AAA8516559

• Gene Names: GSN; ADF; AGEL
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen affinity purified
• Synonyms: GSN; GSN Antibody; ADF; AGEL; anti-GSN antibody

• Reactivity: Human, Mouse, Rat
• Specificity: GSN Antibody detects endogenous levels of total GSN
• Purity/Purification: Immunogen affinity purified
• Form/Format: In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 782

• Applicable Applications for anti-GSN antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: A synthetic peptide of human GSN
• Preparation and Storage: Store at-20 degree C for 1 year

Western Blot (WB)

(Western blot analysis of extracts of RAW264.7cell lysate, using GSN antibody. |Immunohistochemistry of paraffin-embeddedhuman ovarian cancer tissue using GSNantibody.)

Related Product Information for anti-GSN antibody

The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 4504165
• NCBI GeneID: 2934
• NCBI Accession #: NP_000168.1
• NCBI GenBank Nucleotide #: NM_000177.4
• UniProt Accession #: P06396; Q5T0I2; Q8WVV7; A2A418; A8MUD1; A8MYN7; B7Z373; B7Z5V1; F5H1A8
• Molecular Weight: 90kDa
• NCBI Official Full Name: gelsolin isoform a
• NCBI Official Synonym Full Names: gelsolin
• NCBI Official Symbol: GSN
• NCBI Official Synonym Symbols: ADF; AGEL
• NCBI Protein Information: gelsolin
• UniProt Protein Name: Gelsolin
• UniProt Gene Name: GSN
• UniProt Synonym Gene Names: ADF

NCBI Description

The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.