Rabbit anti-Human, Mouse EFNB3 Antibody | anti-EFNB3 antibody

EFNB3 Polyclonal Antibody

Cat. Num. AAA2519438

• Gene Names: EFNB3; EFL6; EPLG8; LERK8
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity purification
• Synonyms: EFNB3; EFNB3 Polyclonal Antibody; EFL6; EPLG8; LERK8; anti-EFNB3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.05% sodium azide and 50% glycerol,PH7.4

• Applicable Applications for anti-EFNB3 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB 1:200-1:1000
• Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Immunogen: Synthetic peptide of human EFNB3
• Preparation and Storage: Store at -20°C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of Mouse brain tissue using EFNB3 Polyclonal Antibody at dilution of 1:300)

Related Product Information for anti-EFNB3 antibody

EFNB3, a member of the ephrin gene family, is important in braindevelopment as well as in its maintenance. Moreover, since levels ofEFNB3 expression were particularly high in several forebrain subregionscompared to other brain subregions, it may play a pivotal role in forebrainfunction. The EPH and EPH-related receptors comprise the largestsubfamily of receptor protein-tyrosine kinases and have been implicatedin mediating developmental events, particularly in the nervous system.EPH Receptors typically have a single kinase domain and an extracellularregion containing a Cys-rich domain and 2 fibronectin type III repeats.

NCBI and Uniprot Product Information

• NCBI GI #: 18490293
• NCBI GeneID: 1949
• Molecular Weight: 36kDa
• NCBI Official Full Name: EFNB3 protein, partial
• NCBI Official Synonym Full Names: ephrin-B3
• NCBI Official Symbol: EFNB3
• NCBI Official Synonym Symbols: EFL6; EPLG8; LERK8
• NCBI Protein Information: ephrin-B3; EPH-related receptor transmembrane ligand ELK-L3; Ephrin B3; eph-related receptor tyrosine kinase ligand 8
• UniProt Protein Name: Ephrin-B3
• Protein Family: Ephrin
• UniProt Gene Name: EFNB3
• UniProt Synonym Gene Names: EPLG8; LERK8; LERK-8
• UniProt Entry Name: EFNB3_HUMAN

NCBI Description

EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

Uniprot Description

EFNB3: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. Belongs to the ephrin family.

Protein type: Cell development/differentiation; Membrane protein, integral; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: ephrin receptor binding; transmembrane-ephrin receptor activity

Biological Process: nervous system development; axon guidance; cell-cell signaling; viral reproduction; axon choice point recognition; ephrin receptor signaling pathway; adult walking behavior