Testing Data
(Gel: 8%SDS-PAGE Lysate: 40ug Mouse brain tissuePrimary antibody: 1/300 dilution Secondary antibody dilution: 1/8000Exposure time: 30 seconds)
Rabbit anti-Human, Mouse EFNB3 Polyclonal Antibody | anti-EFNB3 antibody
EFNB3 Antibody
Testing Data
(Gel: 8%SDS-PAGE Lysate: 40ug Mouse brain tissuePrimary antibody: 1/300 dilution Secondary antibody dilution: 1/8000Exposure time: 30 seconds)
Testing Data
(Gel: 8%SDS-PAGE Lysate: 40ug Mouse brain tissuePrimary antibody: 1/300 dilution Secondary antibody dilution: 1/8000Exposure time: 30 seconds)
NCBI and Uniprot Product Information
NCBI Description
EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
Uniprot Description
EFNB3: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. Belongs to the ephrin family.
Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase; Cell development/differentiation
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: ephrin receptor binding; transmembrane-ephrin receptor activity
Biological Process: axon guidance; nervous system development; cell-cell signaling; viral reproduction; axon choice point recognition; ephrin receptor signaling pathway; adult walking behavior
Research Articles on EFNB3
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Product Notes
The EFNB3 efnb3 (Catalog #AAA9411270) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The EFNB3 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's EFNB3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:200-1:1000. Researchers should empirically determine the suitability of the EFNB3 efnb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EFNB3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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