Rabbit Alternative macrophage activation-associated CC chemokine 1 (AMAC-1) ELISA Kit | AMAC-1 elisa kit
Rabbit Alternative macrophage activation-associated CC chemokine 1 (AMAC-1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]
Uniprot Description
CCL18: Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Chemokine
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: extracellular space
Molecular Function: protein binding; chemokine activity
Biological Process: cell-cell signaling; response to biotic stimulus; immune response; cell communication; signal transduction; chemotaxis; inflammatory response