Rabbit STAT1 alpha Antibody | anti-STAT1 antibody

Anti-STAT1 alpha Antibody

Cat. Num. AAA194142

• Gene Names: STAT1; ISGF-3; STAT91; DKFZp686B04100
• Applications: Immunoblot, Western Blot, Immunoprecipitation
• Synonyms: STAT1 alpha; Anti-STAT1 alpha Antibody; Anti-STAT1 alpha; STAT1a; anti-STAT1 antibody

• Host: Rabbit
• Specificity: Anti-STAT1 alpha [Rabbit antibody to peptide corresponding to aa 712-750 of human STAT1a, a transcription regulator. Recognizes human and mouse STAT1a.]; This antibody recognizes full-length STAT1 alpha (91 kD) and does not react with STAT1 beta .
• Form/Format: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

• Applicable Applications for anti-STAT1 antibody: Immunoblot, Immunoprecipitation
• Application Notes: Immunoblotting : use a1:1,000 dilution.; Immunoprecipitation: use 2-4 ugantibody per sample.; Positive control: Whole cell lysate from HeLa cells, Jurkat cells, or A431 cells.
• Antigen: Peptide corresponding to aa 712-750 of human STAT1 alpha .
• Stabilizer: None
• Preservatives: 0.02% sodium azide.
• Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Related Product Information for anti-STAT1 antibody

STATS (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. STAT1 is activated by many different ligands including the interferon family, gp130 family, and receptpor tyrosine kinases. STAT1 has two forms, the 91 kD STAT1 alpha and the 84 kD STAT1 beta , which are encoded by the same gene with splicing variant.

Product Categories/Family for anti-STAT1 antibody

Neuroscience and Signal Transduction Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 6274552
• NCBI GeneID: 6772
• NCBI Accession #: NP_009330.1
• NCBI GenBank Nucleotide #: NM_007315.3
• UniProt Accession #: P42224; Q53S88; Q53XW4; Q68D00; Q9UDL5; A8K989; B2RCA0; D2KFR8; D3DPI7; Q67C41
• Molecular Weight: 87,335 Da
• NCBI Official Full Name: signal transducer and activator of transcription 1-alpha/beta isoform alpha
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 1, 91kDa
• NCBI Official Symbol: STAT1
• NCBI Official Synonym Symbols: ISGF-3; STAT91; DKFZp686B04100
• NCBI Protein Information: signal transducer and activator of transcription 1-alpha/beta; OTTHUMP00000163552; OTTHUMP00000165046; OTTHUMP00000165047; OTTHUMP00000205845; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription-1
• UniProt Protein Name: Signal transducer and activator of transcription 1-alpha/beta
• Protein Family: Signal transducer and activator of transcription
• UniProt Gene Name: STAT1
• UniProt Entry Name: STAT1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]

Uniprot Description

STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 2q32.2

Cellular Component: nucleoplasm; axon; nuclear chromatin; cytoplasm; dendrite; nucleolus; nucleus; cytosol

Molecular Function: identical protein binding; protein binding; signal transducer activity; protein homodimerization activity; enzyme binding; double-stranded DNA binding; transcription factor activity; tumor necrosis factor receptor binding; CCR5 chemokine receptor binding

Biological Process: transcription from RNA polymerase II promoter; response to peptide hormone stimulus; response to cAMP; viral reproduction; apoptosis; blood circulation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; response to exogenous dsRNA; tumor necrosis factor-mediated signaling pathway; negative regulation of viral protein levels in host cell; positive regulation of mesenchymal cell proliferation; lipopolysaccharide-mediated signaling pathway; defense response to virus; response to nutrient; response to drug; cytokine and chemokine mediated signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; negative regulation of angiogenesis; response to hydrogen peroxide; cellular response to insulin stimulus; response to mechanical stimulus; response to cytokine stimulus; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of transcription from RNA polymerase II promoter

Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c