Rabbit SODD (NT) Antibody | anti-BAG4 antibody

Anti-SODD (NT) Antibody

Cat. Num. AAA194141

• Gene Names: BAG4; SODD; BAG-4; DKFZp586O2022
• Applications: Immunoblot, Western Blot
• Synonyms: SODD (NT); Anti-SODD (NT) Antibody; Anti-SODD (NT); anti-BAG4 antibody

• Host: Rabbit
• Specificity: Anti-SODD (NT) [Rabbit antibody to peptide corresponding to aa 2-16 of human SODD. Recognizes human, mouse, and rat SODD.]; This antibody recognizes human, mouse, and rat SODD (60 kD).
• Form/Format: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

• Applicable Applications for anti-BAG4 antibody: Immunoblot
• Application Notes: Immunoblotting : use at 1:500-1:2,000 dilution.; Positive control: Whole cell lysate from HeLa or THP-1 cells.
• Antigen: Peptide corresponding to aa 2-16 of human SODD.
• Stabilizer: None
• Preservatives: 0.02% sodium azide.
• Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Related Product Information for anti-BAG4 antibody

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. A novel TNFR1- interacting protein was recently identified and designated SODD (silencer of death domains). SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD to engage in the active TNF-R1 complex, thus activating TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

Product Categories/Family for anti-BAG4 antibody

Apoptosis Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 4160014
• NCBI GeneID: 9530
• UniProt Accession #: O95429; O95818
• Molecular Weight: 49,594 Da
• NCBI Official Full Name: silencer of death domains
• NCBI Official Synonym Full Names: BCL2-associated athanogene 4
• NCBI Official Symbol: BAG4
• NCBI Official Synonym Symbols: SODD; BAG-4; DKFZp586O2022
• NCBI Protein Information: BAG family molecular chaperone regulator 4; OTTHUMP00000225745; OTTHUMP00000225746; silencer of death domains; bcl-2-associated athanogene 4; BAG-family molecular chaperone regulator-4
• UniProt Protein Name: BAG family molecular chaperone regulator 4
• Protein Family: BAG family molecular chaperone regulator
• UniProt Gene Name: BAG4
• UniProt Synonym Gene Names: SODD
• UniProt Entry Name: BAG4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]

Uniprot Description

BAG4: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 8p11.23

Cellular Component: plasma membrane; nucleus; cytosol

Molecular Function: protein binding; chaperone binding; receptor signaling protein activity

Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of cell adhesion; protein folding; positive regulation of actin filament polymerization; protein heterooligomerization; positive regulation of stress fiber formation; positive regulation of peptidyl-serine phosphorylation; negative regulation of apoptosis