Rabbit Neurturin Antibody | anti-NRTN antibody

Anti-Neurturin Antibody

Cat. Num. AAA194122

• Gene Names: NRTN; NTN
• Applications: Immunoblot, Western Blot
• Synonyms: Neurturin; Anti-Neurturin Antibody; Anti-Neurturin; anti-NRTN antibody

• Host: Rabbit
• Specificity: Anti-Neurturin [Rabbit antibody to peptide corresponding to aa 178-193 of human neurturin.]; This antibody recognizes human, neurturin (14 kD).
• Form/Format: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

• Applicable Applications for anti-NRTN antibody: Immunoblot
• Application Notes: Immunoblotting: use at 1:500 dilution.
• Antigen: Peptide corresponding to aa 178-193 of human neurturin.
• Stabilizer: None
• Preservatives: 0.02% sodium azide.
• Dilutions Instructions: Dilute in PBS or medium which is identical to that used in the assay system.
• Preparation and Storage: This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.

Related Product Information for anti-NRTN antibody

Glial cell line-derived neurotrophic factor (GDNF) plays a key role in the conrol of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. (NTN). Physiological responses to NTN require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNR alpha . The cDNAS encoding NTNR alpha from human, rat, chicken, and mouse have been cloned and referred to as GFR alpha -2, GDNFR beta , Ret ligand 2 (RETL2), and TGF- beta -related neurotrophic factor receptor 2 (TmR2). NTN forms a complex with GFR alpha -2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations.

Product Categories/Family for anti-NRTN antibody

Neuroscience and Signal Transduction Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 4758826
• NCBI GeneID: 4902
• NCBI Accession #: NP_004549.1
• NCBI GenBank Nucleotide #: NM_004558.3
• UniProt Accession #: Q99748; B2RPE8
• Molecular Weight: 22,405 Da
• NCBI Official Full Name: neurturin preproprotein
• NCBI Official Synonym Full Names: neurturin
• NCBI Official Symbol: NRTN
• NCBI Official Synonym Symbols: NTN
• NCBI Protein Information: neurturin
• UniProt Protein Name: Neurturin
• Protein Family: Neurturin
• UniProt Gene Name: NRTN
• UniProt Entry Name: NRTN_HUMAN

NCBI Description

Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq]

Uniprot Description

NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: axon; extracellular region

Molecular Function: growth factor activity; receptor binding

Biological Process: nervous system development; axon guidance; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Hirschsprung Disease, Susceptibility To, 1