Rabbit anti-Human NRTN Polyclonal Antibody | anti-NRTN antibody

NRTN, ID (NRTN, Neurturin)

Cat. Num. AAA642720

• Gene Names: NRTN; NTN
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: NRTN; Polyclonal Antibody; ID (NRTN; Neurturin); Anti -NRTN; anti-NRTN antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-NRTN antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: NRTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-75 amino acids from the Central region of human NRTN.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(NRTN Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the NRTN antibody detected the NRTN protein (arrow).)

Related Product Information for anti-NRTN antibody

Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq].

Product Categories/Family for anti-NRTN antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4758826
• NCBI GeneID: 4902
• NCBI Accession #: NP_004549.1
• NCBI GenBank Nucleotide #: NM_004558.3
• UniProt Accession #: Q99748; B2RPE8
• Molecular Weight: 22,405 Da
• NCBI Official Full Name: neurturin preproprotein
• NCBI Official Synonym Full Names: neurturin
• NCBI Official Symbol: NRTN
• NCBI Official Synonym Symbols: NTN
• NCBI Protein Information: neurturin
• UniProt Protein Name: Neurturin
• Protein Family: Neurturin
• UniProt Gene Name: NRTN
• UniProt Entry Name: NRTN_HUMAN

NCBI Description

Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Jul 2008]

Uniprot Description

NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: axon; extracellular region

Molecular Function: growth factor activity; receptor binding

Biological Process: nervous system development; axon guidance; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Hirschsprung Disease, Susceptibility To, 1