RAB1A recombinant protein

Recombinant Human RAB1A, Member RAS Oncogene Family

Cat. Num. AAA145222

• Gene Names: RAB1A; RAB1; YPT1
• Purity: Greater than 95% as determined by SDS-PAGE.
• Synonyms: RAB1A; Recombinant Human RAB1A; Member RAS Oncogene Family; RAB1A Human; Member RAS Oncogene Family Recombinant Human; RAB1A member RAS oncogene family; YPT1-related protein; DKFZp564B163; GTP binding protein Rab1a; Rab GTPase YPT1 homolog; RAB1A recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95% as determined by SDS-PAGE.
• Form/Format: The RAB1A protein solution (0.5mg/1ml) is formulated in 20 mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 1mM DTT and 20% glycerol.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MSSMNPEYDY LFKLLLIGDS GVGKSCLLLR FADDTYTESY ISTIGVDFKI RTIELDGKTI KLQIWDTAGQ ERFRTITSSY YRGAHGIIVV YDVTDQESFN NVKQWLQEID RYASENVNKL LVGNKCDLTT KKVVDYTTAK EFADSLGIPF LETSAKNATN VEQSFMTMAA EIKKRMGPGA TAGGAEKSNV KIQSTPVKQS GGGCC
• Sequence Length: 205

Related Product Information for RAB1A recombinant protein

Description: RAB1A produced in E Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids (1-205.a.a) and having a molecular mass of 24.8kDa. RAB1A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: RAB1A belongs to the ras-related superfamily. Rab proteins have a central part in either in endocytosis or in biosynthetic protein transport. Rab1a protein controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus.

Product Categories/Family for RAB1A recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins; Member RAS Oncogene Family

NCBI and Uniprot Product Information

• NCBI GI #: 4758988
• NCBI GeneID: 5861
• NCBI Accession #: NP_004152.1
• NCBI GenBank Nucleotide #: NM_004161.4
• UniProt Accession #: P62820; P11476; Q6FIE7; Q96N61; Q9Y3T2
• Molecular Weight: 13,903 Da
• NCBI Official Full Name: ras-related protein Rab-1A isoform 1
• NCBI Official Synonym Full Names: RAB1A, member RAS oncogene family
• NCBI Official Symbol: RAB1A
• NCBI Official Synonym Symbols: RAB1; YPT1
• NCBI Protein Information: ras-related protein Rab-1A; GTP binding protein Rab1a; RAB1, member RAS oncogene family; Rab GTPase YPT1 homolog; YPT1-related protein
• UniProt Protein Name: Ras-related protein Rab-1A
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB1A
• UniProt Synonym Gene Names: RAB1
• UniProt Entry Name: RAB1A_HUMAN

NCBI Description

This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

Uniprot Description

RAB1A: Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rab family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric; G protein, monomeric, Rab; G protein

Chromosomal Location of Human Ortholog: 2p14

Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; early endosome; melanosome; cytosol

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding

Biological Process: ER to Golgi vesicle-mediated transport; cell migration; endocytosis; virus assembly; melanosome transport; vesicle-mediated transport; growth hormone secretion; intracellular protein transport; defense response to bacterium; vesicle transport along microtubule; autophagy; cilium biogenesis; mitotic cell cycle; Rab protein signal transduction; Golgi organization and biogenesis; autophagic vacuole formation