Glycogen phosphorylase, liver form (Pygl) Recombinant Protein | Pygl recombinant protein

Recombinant Rat Glycogen phosphorylase, liver form (Pygl) , partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Glycogen phosphorylase; liver form (Pygl); Recombinant Rat Glycogen phosphorylase; partial; Pygl recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 850

• Species: Rat
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Pygl recombinant protein

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, or Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.

NCBI and Uniprot Product Information

• NCBI GI #: 11560087
• NCBI GeneID: 64035
• NCBI Accession #: NP_071604.1
• NCBI GenBank Nucleotide #: NM_022268.1
• UniProt Accession #: P09811
• Molecular Weight: 97,483 Da
• NCBI Official Full Name: glycogen phosphorylase, liver form
• NCBI Official Synonym Full Names: glycogen phosphorylase L
• NCBI Official Symbol: Pygl
• NCBI Protein Information: glycogen phosphorylase, liver form
• UniProt Protein Name: Glycogen phosphorylase, liver form
• Protein Family: Glycogen phosphorylase
• UniProt Gene Name: Pygl
• UniProt Synonym Gene Names: Lgp

NCBI Description

catalyzes the rate-limiting step of glycogen catabolism [RGD, Feb 2006]

Uniprot Description

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.