PRL3 Blocking Peptide | PTP4A3 blocking peptide

PRL3 Antibody (C-term) Blocking Peptide

• Gene Names: PTP4A3; PRL3; PRL-3; PRL-R
• Synonyms: PRL3; PRL3 Antibody (C-term) Blocking Peptide; Protein tyrosine phosphatase type IVA 3; PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3; PTP4A3; PTP4A3 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human PRL3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 173

• Cellular Location: Cell membrane. Early endosome
• Tissue Location: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PTP4A3 blocking peptide

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

NCBI and Uniprot Product Information

• NCBI GI #: 68566154
• NCBI GeneID: 11156
• UniProt Accession #: O75365; Q8IVN5; Q99849; Q9BTW5
• Molecular Weight: 10,494 Da
• NCBI Official Full Name: Protein tyrosine phosphatase type IVA 3
• NCBI Official Synonym Full Names: protein tyrosine phosphatase type IVA, member 3
• NCBI Official Symbol: PTP4A3
• NCBI Official Synonym Symbols: PRL3; PRL-3; PRL-R
• NCBI Protein Information: protein tyrosine phosphatase type IVA 3
• UniProt Protein Name: Protein tyrosine phosphatase type IVA 3
• Protein Family: Protein tyrosine phosphatase
• UniProt Gene Name: PTP4A3
• UniProt Synonym Gene Names: PRL3; PRL-3
• UniProt Entry Name: TP4A3_HUMAN

NCBI Description

This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

PTP4A3: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. Belongs to the protein-tyrosine phosphatase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: cytoplasm; nucleus

Molecular Function: prenylated protein tyrosine phosphatase activity

Biological Process: endothelial cell migration