Testing Data
(The TFact GATA4 (Phospho-Ser262) DNA-Binding ELISA detects active GATA4 (Phospho-Ser262) in Jurkat Nuclear Extract. The Jurkat cells were grown 3 days in RPMI 1640 with 10% FBS and harvested for nuclear extract. The DNA-transcription factor complex is treated with stablization buffer.)
Human, Mouse GATA4 ELISA Kit | GATA4 elisa kit
GATA4 (Phospho-Ser262) TFact DNA-Binding ELISA Kit
Testing Data
(The TFact GATA4 (Phospho-Ser262) DNA-Binding ELISA detects active GATA4 (Phospho-Ser262) in Jurkat Nuclear Extract. The Jurkat cells were grown 3 days in RPMI 1640 with 10% FBS and harvested for nuclear extract. The DNA-transcription factor complex is treated with stablization buffer.)
Testing Data
(The TFact GATA4 (Phospho-Ser262) DNA-Binding ELISA detects active GATA4 (Phospho-Ser262) in Jurkat Nuclear Extract. The Jurkat cells were grown 3 days in RPMI 1640 with 10% FBS and harvested for nuclear extract. The DNA-transcription factor complex is treated with stablization buffer.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Description
GATA4: a conserved and ubiquitous member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. May regulate a set of cardiac-specific genes and play a crucial role in cardiogenesis. Defects are a cause of atrial septal defect 2 (ASD2). ASD2 is an autosomal dominant condition with atrial septal defect and other congenital heart disease but no conduction defects or noncardiac abnormalities.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: nuclear body; nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function: activating transcription factor binding; chromatin binding; co-SMAD binding; DNA binding; DNA binding transcription factor activity; NFAT protein binding; protein binding; protein kinase binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; transcription regulatory region DNA binding; zinc ion binding
Biological Process: atrial septum primum morphogenesis; atrial septum secundum morphogenesis; blood coagulation; cardiac right ventricle morphogenesis; cardiac ventricle morphogenesis; cell-cell signaling; cellular response to glucose stimulus; embryonic foregut morphogenesis; embryonic heart tube anterior/posterior pattern formation; endocardial cushion development; endoderm development; heart looping; male gonad development; negative regulation of autophagy; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of vascular endothelial growth factor production; regulation of cardiac muscle cell contraction; regulation of transcription, DNA-templated; response to drug; response to mechanical stimulus; response to vitamin A; transcription from RNA polymerase II promoter; ventricular septum development
Disease: Atrial Septal Defect 2; Atrioventricular Septal Defect 4; Testicular Anomalies With Or Without Congenital Heart Disease; Tetralogy Of Fallot; Ventricular Septal Defect 1
Research Articles on GATA4
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Product Notes
The Human, Mouse GATA4 gata4 (Catalog #AAA9502183) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9502183 ELISA Kit recognizes Human, Mouse GATA4. It is sometimes possible for the material contained within the vial of "GATA4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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