Typical Testing Data/Standard Curve (for reference only)
Rat Focal adhesion kinase 1 ELISA Kit | Ptk2 elisa kit
Rat Focal adhesion kinase 1 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
tyrosine kinase that is enriched in focal adhesions; may regulate mechanical signal transduction in cardiac myocytes [RGD, Feb 2006]
Uniprot Description
FAK: a tyrosine kinase of the FAK family required for cell migration and contact-dependent survival signaling. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Downstream of integrins and Src, upstream of Ras/MAPK. Localizes to focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with Shb. Required for full Ras transformation of fibroblasts. Increased expression in breast and other cancers, related to chromosome 8q amplification. Overexpression and activation associated with increased migration, invasion and progression of ovarian cancer, and with progression in hepatocellular carcinoma, thyroid cancer, and acute myelogenous leukemia. siRNA increases chemosensitivity of pancreatic adenocarcinoma xenografts. Inhibitor: ISI15421 (antisense). Four splice-variant isoforms have been observed.
Protein type: Protein kinase, TK; Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Fak family
Cellular Component: apical plasma membrane; basolateral plasma membrane; cytoplasm; cytoskeleton; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; lamellipodium; microtubule organizing center; nuclear body; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; sarcolemma; stress fiber
Molecular Function: actin binding; ATP binding; identical protein binding; integrin binding; JUN kinase binding; non-membrane spanning protein tyrosine kinase activity; phosphoinositide 3-kinase binding; protein binding; protein complex binding; protein kinase binding; protein-tyrosine kinase activity; SH2 domain binding; signal transducer activity
Biological Process: angiogenesis; blood vessel development; cell adhesion; cellular chloride ion homeostasis; central nervous system neuron axonogenesis; cytoskeleton organization and biogenesis; endothelial cell migration; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; establishment of nucleus localization; extracellular matrix organization and biogenesis; fat cell differentiation; innate immune response; integrin-mediated signaling pathway; JNK cascade; MAPKKK cascade; microtubule cytoskeleton organization and biogenesis; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of cell migration; negative regulation of cell-cell adhesion; negative regulation of organ growth; negative regulation of synaptogenesis; neuron migration; peptidyl-tyrosine phosphorylation; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of phagocytosis; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling cascade; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of synaptic transmission; positive regulation of vasodilation; protein amino acid autophosphorylation; regulation of cell adhesion mediated by integrin; regulation of cell proliferation; regulation of cell shape; regulation of focal adhesion formation; regulation of osteoblast differentiation; regulation of protein amino acid phosphorylation; response to arsenic; response to drug; response to estradiol stimulus; response to glucose stimulus; response to mechanical stimulus; response to organic cyclic substance; response to organic nitrogen; response to organic substance; signal complex assembly; signal transduction; transforming growth factor beta receptor signaling pathway; vasculogenesis
Research Articles on Ptk2
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Product Notes
The Rat Ptk2 ptk2 (Catalog #AAA2882324) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2882324 ELISA Kit recognizes Rat Ptk2. It is sometimes possible for the material contained within the vial of "Focal adhesion kinase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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