Polypyrimidine tract-binding protein 1 (Ptbp1) Recombinant Protein | Ptbp1 recombinant protein

Recombinant Mouse Polypyrimidine tract-binding protein 1 (Ptbp1)

Cat. Num. AAA954748

• Gene Names: Ptbp1; Ptb; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; AA407203; AL033359
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Polypyrimidine tract-binding protein 1 (Ptbp1); Recombinant Mouse Polypyrimidine tract-binding protein 1 (Ptbp1); Ptbp1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-527, Full length protein
• Sequence: MDGIVPDIAVGTKRGSDELFSTCVSNGPFIMSSSASAANGNDSKKFKGDNRSAGVPSRVIHVRKLPSDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVAPVLRGQPIYIQFSNHKELKTDSSPNQVRAQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDSQPSLDQTMAAAFGLSVPNVHGALAPLAIPSAAAAAAASRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADGSQAQLGEPPERAQAAREVSAHYTVQASECAAAREGQEDQGLTKDYGSSPLRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEDDLKSLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIELHNHDLGENHHLRVSFSKSTI
• Sequence Length: 527

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Ptbp1 recombinant protein

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. This protein has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

NCBI and Uniprot Product Information

• NCBI GI #: 131529
• NCBI GeneID: 19205
• UniProt Accession #: P17225
• Molecular Weight: 56,478 Da
• NCBI Official Full Name: Polypyrimidine tract-binding protein 1
• NCBI Official Synonym Full Names: polypyrimidine tract binding protein 1
• NCBI Official Symbol: Ptbp1
• NCBI Official Synonym Symbols: Ptb; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; AA407203; AL033359
• NCBI Protein Information: polypyrimidine tract-binding protein 1
• UniProt Protein Name: Polypyrimidine tract-binding protein 1
• Protein Family: Polypyrimidine tract-binding protein
• UniProt Gene Name: Ptbp1
• UniProt Synonym Gene Names: Ptb; PTB; hnRNP I

Uniprot Description

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.