Proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1) Recombinant Protein | Pstpip1 recombinant protein

Recombinant Mouse Proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1)

Cat. Num. AAA953837

• Gene Names: Pstpip1; def-2; CD2BP1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1); Recombinant Mouse Proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1); Pstpip1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-415, Full length protein
• Sequence: MMAQLQFRDAFWCRDFTAHTGYEVLLQRLLDGRKMCKDVEELLRQRAQAEERYGKELVQIARKAGGQTEMNSLRTSFDSLKQQTENVGSAHIQLALALREELRSLEEFRERQKEQRKKYEAIMDRVQKSKLSLYKKTMESKKAYDQKCRDADDAEQAFERVSANGHQKQVEKSQNKAKQCKESATEAERVYRQNIEQLERARTEWEQEHRTTCEAFQLQEFDRLTILRNALWVHCNQLSMQCVKDDELYEEVRLTLEGCDVEGDINGFIQSKSTGREPPAPVPYQNYYDREVTPLIGSPSIQPSCGVIKRFSGLLHGSPKTTPSAPAASTETLTPTPERNELVYASIEVQATQGNLNSSAQDYRALYDYTAQNSDELDISAGDILAVILEGEDGWWTVERNGQRGFVPGSYLEKL
• Sequence Length: 415

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Pstpip1 recombinant protein

This protein binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome.

NCBI and Uniprot Product Information

• NCBI GI #: 171184423
• NCBI GeneID: 19200
• NCBI Accession #: NP_035323.2
• NCBI GenBank Nucleotide #: NM_011193.3
• UniProt Accession #: P97814; Q4V9R4
• Molecular Weight: 47,590 Da
• NCBI Official Full Name: proline-serine-threonine phosphatase-interacting protein 1
• NCBI Official Synonym Full Names: proline-serine-threonine phosphatase-interacting protein 1
• NCBI Official Symbol: Pstpip1
• NCBI Official Synonym Symbols: def-2; CD2BP1
• NCBI Protein Information: proline-serine-threonine phosphatase-interacting protein 1
• UniProt Protein Name: Proline-serine-threonine phosphatase-interacting protein 1
• Protein Family: Proline-serine-threonine phosphatase-interacting protein
• UniProt Gene Name: Pstpip1
• UniProt Synonym Gene Names: PEST phosphatase-interacting protein 1

Uniprot Description

Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.