Rat PSMC3 interacting protein ELISA Kit | PSMC3IP elisa kit
Rat Homologous-pairing protein 2 homolog, PSMC3IP ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
interacts with nuclear receptors, estrogen receptor alpha and beta, thyroid hormone receptor beta1, androgen receptor, glucocorticoid receptor, and progesterone receptor [RGD, Feb 2006]
Uniprot Description
PSMC3IP: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Acts as a tissue specific coactivator of hormone-dependent transcription mediated by nuclear receptors. Defects in PSMC3IP are the cause of ovarian dysgenesis type 3 (ODG3). A disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. Belongs to the HOP2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator
Cellular Component: proteasome complex; nucleus
Molecular Function: protein dimerization activity; DBD domain binding; protein homodimerization activity; androgen receptor binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; estrogen receptor binding; thyroid hormone receptor binding; glucocorticoid receptor binding
Biological Process: meiotic cell cycle; positive regulation of transcription from RNA polymerase II promoter; DNA recombination
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Product Notes
The Rat PSMC3IP psmc3ip (Catalog #AAA9332211) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332211 ELISA Kit recognizes Rat PSMC3IP. It is sometimes possible for the material contained within the vial of "PSMC3 interacting protein, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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