Figure
(Figure 1. Illustration of the replication-deficient MLV particle pseudotyped with SARS-CoV-2 Spike protein)
SARS-CoV-2 Pseudoviral Particles, Lambda Variant (Lineage C.37) Pseudovirus
SARS-CoV-2 Pseudoviral Particles, Lambda Variant (Lineage C.37)
Synonyms
SARS-CoV-2 Pseudoviral Particles; Lambda Variant (Lineage C.37); Lambda Variant (Lineage C.37) pseudovirus
Form/Format
10 ml (2 tubes, 5 mL/tube), for 2 multi-well plates
Application Notes
Our Pseudovirus Particles generate robust chemiluminescent signals in cell assays when coupled with our firefly luciferase assay kit (Catalog # MBS434279), useful for 1) screening potential inhibitor to block SARS-CoV-2 entry and viral protein translation; 2) measuring the activity of and screening for neutralizing antibody against SARS-CoV-2-Lambda
Features
Robust: Excellent signal to noise (basal) ratio
Easy to use: Amenable to HTS format (96-well, 384-well and 1536-well format)
Easy to use: Amenable to HTS format (96-well, 384-well and 1536-well format)
Shipping Note
MBS434310 is available for shipment in the United States, Canada and European countries. Please inquire for shipment to other countries.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Upon receiving it, store at -70 degree C right away. Thaw before immediate use (Do not aliquot and refreeze). Shelf Life: Six months from the date of shipping when stored at -70 degree C
Figure
(Figure 1. Illustration of the replication-deficient MLV particle pseudotyped with SARS-CoV-2 Spike protein)
Figure
(Figure 1. Illustration of the replication-deficient MLV particle pseudotyped with SARS-CoV-2 Spike protein)
Sequence
(Figure 2. Protein sequence of the Lambda spike in SCV2-PsV-Lambda pseudoviral particles)
Sequence
(Figure 2. Protein sequence of the Lambda spike in SCV2-PsV-Lambda pseudoviral particles)
Testing Data
(Figure 3. Pseudoviral Particle (PP) Infection assays(SARS-CoV-2-Lambda variant pseudoviral particles on HEK293-ACE2 cells)Legends: SARS-2-CoV-Lambda: SARS-CoV-2 Lambda variant MLV Pseudovirus Particles (SCV2-PsV-Lambda)(-): MLV control (w/o envelope spike protein) (Catalog # MBS434280))
Testing Data
(Figure 3. Pseudoviral Particle (PP) Infection assays(SARS-CoV-2-Lambda variant pseudoviral particles on HEK293-ACE2 cells)Legends: SARS-2-CoV-Lambda: SARS-CoV-2 Lambda variant MLV Pseudovirus Particles (SCV2-PsV-Lambda)(-): MLV control (w/o envelope spike protein) (Catalog # MBS434280))
Related Product Information for SARS-CoV-2 Pseudoviral Particles, Lambda Variant (Lineage C.37) pseudovirus
It has been known that SARS coronavirus 2 (SARS-CoV-2) uses human ACE2 as entry receptor and human proteases as entry activators. The virus surface spike protein (S) mediates SARS-CoV-2 entry into cells. To fulfill its function, SARS-CoV-2 spike binds to its human ACE2 (hACE2) receptor through its receptor-binding domain (RBD) and is proteolytically activated by human proteases.
Our SARS-CoV-2-Lambda Pseudoviral Particles are replication-deficient MLV pseudotyped with the SARS-CoV-2 spike protein (Accession ID: EPI_ISL_3274616) of the Lamdba variant, originally known as lineage C.37. They also contain the ORF for firefly luciferase as a reporter. They establish a pseudovirus cell entry assay mediated by the SARS-CoV-2 spike protein that can be conveniently measured via luciferase reporter activity. This pseudovirus assay isolates the SARS-CoV-2 viral entry from other steps of the viral infection cycle.
Our SARS-CoV-2-Lambda Pseudoviral Particles are replication-deficient MLV pseudotyped with the SARS-CoV-2 spike protein (Accession ID: EPI_ISL_3274616) of the Lamdba variant, originally known as lineage C.37. They also contain the ORF for firefly luciferase as a reporter. They establish a pseudovirus cell entry assay mediated by the SARS-CoV-2 spike protein that can be conveniently measured via luciferase reporter activity. This pseudovirus assay isolates the SARS-CoV-2 viral entry from other steps of the viral infection cycle.
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Product Notes
The SARS-CoV-2 Pseudoviral Particles, Lambda Variant (Lineage C.37) (Catalog #AAA434310) is a Pseudovirus and is intended for research purposes only. The product is available for immediate purchase. Our Pseudovirus Particles generate robust chemiluminescent signals in cell assays when coupled with our firefly luciferase assay kit (Catalog # MBS434279), useful for 1) screening potential inhibitor to block SARS-CoV-2 entry and viral protein translation; 2) measuring the activity of and screening for neutralizing antibody against SARS-CoV-2-Lambda. Researchers should empirically determine the suitability of the SARS-CoV-2 Pseudoviral Particles, Lambda Variant (Lineage C.37) for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SARS-CoV-2 Pseudoviral Particles, Lambda Variant (Lineage C.37), Pseudovirus" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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