Human Pre-mRNA-processing factor 6 ELISA Kit | PRPF6 elisa kit
Human Pre-mRNA-processing factor 6 (PRPF6) ELISA Kit
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008]
Uniprot Description
PRPF6: Involved in pre-mRNA splicing. May act in the tri-snRNP complex as a bridging factor between U5 and U4/U6 snRNPs in the late step of spliceosome assembly. May be necessary for tri-snRNP formation. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Defects in PRPF6 may be the cause of retinitis pigmentosa type 60 (RP60). A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Cells from RP60 patients show intron retention for pre-mRNA bearing specific splicing signals. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: membrane; nuclear speck; nucleoplasm; nucleus; snRNP U5; spliceosomal complex; U4/U6 x U5 tri-snRNP complex
Molecular Function: androgen receptor binding; protein binding; ribonucleoprotein complex binding; RNA binding; transcription coactivator activity
Biological Process: mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; RNA localization; RNA splicing; RNA splicing, via transesterification reactions; spliceosomal complex assembly; spliceosomal tri-snRNP complex assembly
Disease: Retinitis Pigmentosa 60
Research Articles on PRPF6
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Product Notes
The Human PRPF6 prpf6 (Catalog #AAA280317) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA280317 ELISA Kit recognizes Human PRPF6. It is sometimes possible for the material contained within the vial of "Pre-mRNA-processing factor 6, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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