Brain Natriuretic Peptide (BNP) Small Molecule | BNP small molecule

OVA Conjugated Brain Natriuretic Peptide (BNP)

Cat. Num. AAA2086200

• Gene Names: NPPB; BNP
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Brain Natriuretic Peptide (BNP); OVA Conjugated Brain Natriuretic Peptide (BNP); GC-B; NPPB; B-Type Natriuretic Peptide; Natriuretic Peptide Precursor B; Gamma-brain natriuretic peptide; Brain natriuretic peptide 32; BNP small molecule

• Host: Protein Conjugation
• Purity/Purification: > 90%
• Form/Format: Freeze-dried powder
• Sequence Length: 1

• Applicable Applications for BNP small molecule: Immunogen, SDS-PAGE, Western Blot (WB)
• Buffer Formulation: PBS, pH7.4.
• Organism Species: Human
• Usage: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Sequence Information

Testing Data

Product Categories/Family for BNP small molecule

Conjugated small molecules

NCBI and Uniprot Product Information

• NCBI GI #: 4433127
• NCBI GeneID: 4879
• Molecular Weight: 14,726 Da
• NCBI Official Full Name: brain natriuretic peptide, partial
• NCBI Official Synonym Full Names: natriuretic peptide B
• NCBI Official Symbol: NPPB
• NCBI Official Synonym Symbols: BNP
• NCBI Protein Information: natriuretic peptides B
• UniProt Protein Name: Natriuretic peptides B
• UniProt Gene Name: NPPB
• UniProt Synonym Gene Names: BNP(1-32); BNP-32

NCBI Description

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

Uniprot Description

NPPB: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: extracellular region; protein complex

Molecular Function: diuretic hormone activity; protein binding; receptor binding

Biological Process: body fluid secretion; cGMP biosynthetic process; negative regulation of angiogenesis; receptor guanylyl cyclase signaling pathway; regulation of vascular permeability