Rabbit Dlx-3 Polyclonal Antibody | anti-Dlx-3 antibody

Dlx-3 (D107) Polyclonal Antibody

Cat. Num. AAA3001817

• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Dlx-3; Polyclonal Antibody; Dlx-3 (D107) Polyclonal Antibody; DLX3; Homeobox protein DLX-3; anti-Dlx-3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Dlx-3 (D107) polyclonal antibody detects endogenous levels of Dlx-3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 287

• Applicable Applications for anti-Dlx-3 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 71-120 of Human Dlx-3.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of Dlx-3 (D107) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.)

Related Product Information for anti-Dlx-3 antibody

Dlx genes are a highly conserved family of six different (Dlx1-6) homeo boxcontaining genes that share homology with distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. Dlx genes are expressed in spatially and temporally restricted patterns in craniofacial primordia, basal telencephalon and diencephalon, and in distal regions of extending appendages, including the limb and the genital bud. The differential expression of Dlx influences patterning, morphogenesis and histogenesis in these tissues. The Dlx gene products can activate transcription and are localized primarily to the nucleus, although Dlx-5 can be found in the cytoplasm. Dlx proteins influence different stages of proper tissue development, including patterning of the orofacial skeleton (craniofacial ectomesenchyme) and differentiation of structures within and between teeth.

NCBI and Uniprot Product Information

• NCBI GI #: 4885185
• NCBI Accession #: NP_005211.1
• NCBI GenBank Nucleotide #: NP_005211.1
• UniProt Accession #: O60479
• Molecular Weight: ~ 45kDa
• NCBI Official Full Name: homeobox protein DLX-3
• UniProt Protein Name: Homeobox protein DLX-3
• UniProt Gene Name: DLX3
• UniProt Entry Name: DLX3_HUMAN

Uniprot Description

DLX3: Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis. Defects in DLX3 are a cause of trichodentoosseous syndrome (TDO). TDO is an autosomal dominant syndrome characterized by enamel hypoplasia and hypocalcification with associated strikingly curly hair. Defects in DLX3 are the cause of amelogenesis imperfecta type 4 (AI4); also known as amelogenesis imperfecta hypomaturation-hypoplastic type with taurodontism. AI4 is an autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Belongs to the distal-less homeobox family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; chromatin binding; transcription factor activity

Biological Process: blood vessel development; positive regulation of transcription from RNA polymerase II promoter; placenta development; odontogenesis of dentine-containing teeth

Disease: Amelogenesis Imperfecta, Type Iv; Trichodentoosseous Syndrome