Prolactin Receptor (PRLR) Recombinant Protein | PRLR recombinant protein

Recombinant Prolactin Receptor (PRLR)

Cat. Num. AAA2009593

• Gene Names: Prlr; RATPRLR
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Prolactin Receptor (PRLR); Recombinant Prolactin Receptor (PRLR); PRLR recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with N-terminal His-Tag, its sequence is listed below.; MGHHHHHHSGSEF-Q SPPGKPEIHK CRSPDKETFT CWWNPGTDGG LPTNYSLTYS KEGEKTTYEC PDYKTSGPNS CFFSKQYTSI WKIYIITVNA TNQMGSSSSD PLYVDVTYIV EPEPPRNLTL EVKQLKDKKT YLWVKWSPPT ITDVKTGWFT MEYEIRLKPE EAEEWEIHFT GHQTQFKVFD LYPGQKYLVQ TRCKPDHGYW SRWSQESSVE MPNDFTLKD
• Sequence Length: 610

• Applicable Applications for PRLR recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Rattus norvegicus (Rat)
• Expression System: Prokaryotic expression
• Residues: Gln20~Asp229 (Accession # P05710) with N-terminal His-Tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

NCBI and Uniprot Product Information

• NCBI GI #: 77627969
• NCBI GeneID: 24684
• NCBI Accession #: NP_001029283.1
• NCBI GenBank Nucleotide #: NM_001034111.1
• UniProt Accession #: P05710; Q62832; Q63451; Q63479; Q63723; Q64274
• Molecular Weight: 26.1kDa
• NCBI Official Full Name: prolactin receptor isoform a
• NCBI Official Synonym Full Names: prolactin receptor
• NCBI Official Symbol: Prlr
• NCBI Official Synonym Symbols: RATPRLR
• NCBI Protein Information: prolactin receptor; PRL-R; lactogen receptor
• UniProt Protein Name: Prolactin receptor
• Protein Family: Prolactin receptor
• UniProt Gene Name: Prlr
• UniProt Synonym Gene Names: PRL-R
• UniProt Entry Name: PRLR_RAT

Uniprot Description

PRLR: receptor for the anterior pituitary hormone prolactin and placental lactogen I and II. Interacts with Cyclophilin A, differentially regulating various signaling pathways from the PrlR. Prolactin signaling is attenuated by threonine and tyrosine phosphorylation. Two alternative splice isoforms have been identified.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; intracellular

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; peptide hormone binding; metal ion binding; protein kinase binding; prolactin receptor activity

Biological Process: lactation; regulation of cell adhesion; transmembrane receptor protein tyrosine kinase activation (dimerization); cytokine and chemokine mediated signaling pathway; regulation of epithelial cell differentiation; JAK-STAT cascade