Human protein kinase, interferon-inducible double stranded RNA dependent activator ELISA Kit | PRKRA elisa kit
Human Interferon-inducible double stranded RNA-dependent protein kinase activator A, PRKRA ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Uniprot Description
PACT: a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. Three alternatively spliced human isoforms have been reported.
Protein type: Activator; RNA-binding; RNA processing
Chromosomal Location of Human Ortholog: 2q31.2
Cellular Component: nucleoplasm; membrane; perinuclear region of cytoplasm; cytoplasm; cytosol
Molecular Function: protein binding; protein homodimerization activity; enzyme activator activity
Biological Process: positive regulation of catalytic activity; negative regulation of cell proliferation; skeletal morphogenesis; response to virus; outer ear morphogenesis; gene expression; immune response; middle ear morphogenesis; RNA interference, production of siRNA; protein amino acid phosphorylation
Disease: Dystonia 16
Research Articles on PRKRA
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Product Notes
The Human PRKRA prkra (Catalog #AAA9318120) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318120 ELISA Kit recognizes Human PRKRA. It is sometimes possible for the material contained within the vial of "protein kinase, interferon-inducible double stranded RNA dependent activator, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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