Rabbit anti-Human RAX Polyclonal Antibody | anti-RAX antibody

RAX Polyclonal Antibody

Cat. Num. AAA668077

• Gene Names: PRKRA; RAX; PACT; DYT16; HSD14
• Reactivity: Human
• Applications: Western Blot
• Synonyms: RAX; Polyclonal Antibody; RAX Polyclonal Antibody; anti-RAX antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Form/Format: Purified (Liquid)
• Concentration: 0.5mg/ml, 200µl (varies by lot)
• Sequence Length: 302

• Applicable Applications for anti-RAX antibody: Western Blot (WB)
• Application Notes: Western Blot: 1-2 µg/ml
• Antigen: RAX
• Immunogen: A partial recombinant RAX protein (amino acids 100-313) was used as the immunogen for this antibody.
• Preparation and Storage: Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.

Western Blot (WB)

(Expression analysis of Rax. Anti-Rax antibody (11-13004) was used at 1 µg/ml on K562 lysate.)

NCBI and Uniprot Product Information

• NCBI GI #: 213417911
• NCBI GeneID: 8575
• NCBI Accession #: NP_001132989.1
• NCBI GenBank Nucleotide #: NM_001139517.1
• UniProt Accession #: O75569; Q53G24; Q6X7T5; Q8NDK4; A8K3I6
• Molecular Weight: 31,635 Da
• NCBI Official Full Name: interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 2
• NCBI Official Synonym Full Names: protein kinase, interferon-inducible double stranded RNA dependent activator
• NCBI Official Symbol: PRKRA
• NCBI Official Synonym Symbols: RAX; PACT; DYT16; HSD14
• NCBI Protein Information: interferon-inducible double-stranded RNA-dependent protein kinase activator A; PKR-associated protein X; PKR-associating protein X; interferon-inducible double stranded RNA-dependent protein kinase activator A; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double stranded RNA-dependent activator; protein kinase, interferon-inducible double-stranded RNA-dependent activator
• UniProt Protein Name: Interferon-inducible double-stranded RNA-dependent protein kinase activator A
• Protein Family: Retinal homeobox protein
• UniProt Gene Name: PRKRA
• UniProt Synonym Gene Names: PACT; RAX
• UniProt Entry Name: PRKRA_HUMAN

NCBI Description

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Uniprot Description

PACT: a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. Three alternatively spliced human isoforms have been reported.

Protein type: RNA-binding; RNA processing; Activator

Chromosomal Location of Human Ortholog: 2q31.2

Cellular Component: nucleoplasm; membrane; perinuclear region of cytoplasm; cytoplasm; cytosol

Molecular Function: protein binding; protein homodimerization activity; enzyme activator activity

Biological Process: positive regulation of catalytic activity; negative regulation of cell proliferation; skeletal morphogenesis; response to virus; outer ear morphogenesis; gene expression; immune response; middle ear morphogenesis; protein amino acid phosphorylation; RNA interference, production of siRNA

Disease: Dystonia 16