PKC alpha recombinant protein

PKC alpha protein

Cat. Num. AAA5304303

• Gene Names: PRKCA; PKRCA
• Purity: PKC alpha protein was purified using a a proprietary chromatographic technique.
• Synonyms: PKC alpha; PKC alpha protein; Protein kinase C alpha protein; PKCalpha protein; PKC protein; PKC alpha recombinant protein

• Host: Human
• Purity/Purification: PKC alpha protein was purified using a a proprietary chromatographic technique.
• Form/Format: Supplied in a storage buffer consisting of 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF and 25% glycerol
• Sequence Length: 672

• Protein Type: Recombinant
• Biological Significance: Protein kinase C is a family of serine-and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. PKC-alpha has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control.
• Expression System: Sf-9 insect cells
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Store at -80 degree C

Related Product Information for PKC alpha recombinant protein

Purified recombinant Human PKC alpha protein

Product Categories/Family for PKC alpha recombinant protein

Proteases; Inhibitors; & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 27806089
• NCBI GeneID: 282001
• NCBI Accession #: NP_776860.1
• NCBI GenBank Nucleotide #: NM_174435.1
• Molecular Weight: 103 kDa
• NCBI Official Full Name: protein kinase C alpha type
• NCBI Official Symbol: PRKCA
• NCBI Official Synonym Symbols: PKRCA
• NCBI Protein Information: protein kinase C alpha type
• UniProt Protein Name: Protein kinase C alpha type
• UniProt Gene Name: PRKCA
• UniProt Synonym Gene Names: PKC-A; PKC-alpha
• UniProt Entry Name: KPCA_BOVIN

Uniprot Description

PKCA: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators.

Protein type: EC 2.7.11.13; Protein kinase, AGC; Oncoprotein; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Alpha subfamily

Cellular Component: perinuclear region of cytoplasm; cytoplasm; mitochondrial membrane; plasma membrane; cytosol; nucleus

Molecular Function: protein binding; protein kinase C activity; zinc ion binding; ATP binding

Biological Process: positive regulation of angiogenesis; positive regulation of cell adhesion; apoptosis; adenylate cyclase activation; negative regulation of adenylate cyclase activity; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of endothelial cell proliferation; angiogenesis; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; cell adhesion; protein amino acid phosphorylation; positive regulation of cell migration