Uniprot Description
PRG4: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Defects in PRG4 are the cause of camptodactyly- arthropathy-coxa vara-pericarditis syndrome (CACP); also known as Jacobs syndrome. CACP is an autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular region; extracellular space
Molecular Function: polysaccharide binding; scavenger receptor activity
Biological Process: immune response; negative regulation of interleukin-6 biosynthetic process; regulation of cell proliferation
Product Notes
The Mouse Prg4 prg4 (Catalog #
AAA2880817) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2880817 ELISA Kit recognizes Mouse Prg4.
It is sometimes possible for the material contained within the vial of
"Proteoglycan 4, ELISA Kit" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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