NAP-2 (CXCL7) Recombinant Protein | NAP-2 recombinant protein
Human NAP-2 (CXCL7) Recombinant
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
and propeptide and has a calculated molecular mass of approximately 8 kDa.
Recombinant NAP-2 is a disulfide-linked monomeric protein consisting of 71 amino acid residue subunits and migrates as an approximately 8 kDa protein under non-reducing conditions and reducing conditions in SDS-PAGE.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.
Avoid repeated freeze/thaw cycles.
• thrombopoietin-induced cxc chemokines, NAP-2 and pf4, suppress polyploidization and proplatelet formation during megakaryocyte maturation .Genes Cells, Jan 2003; 8: 9 - 15.
• chemotactic activity of human blood leukocytes in plasma treated with edta: chemoattraction of neutrophils about monocytes is mediated by the generation of NAP-2 .J. Leukoc. Biol., Jul 2002; 72: 175.
• limited and defined truncation at the c terminus enhances receptor binding and degranulation activity of the neutrophil-activating peptide 2 (NAP-2) .J. Biol. Chem., Mar 1995; 270: 6338.
• diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or gro alpha, stimulates phospholipase d activity .Blood, Jan 1995; 85: 522 - 531.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]
Uniprot Description
PPBP: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. Belongs to the intercrine alpha (chemokine CxC) family.
Protein type: Secreted; Secreted, signal peptide; Chemokine
Chromosomal Location of Human Ortholog: 4q12-q13
Cellular Component: extracellular space; extracellular region
Molecular Function: growth factor activity; chemokine activity; CXCR chemokine receptor binding; glucose transmembrane transporter activity
Biological Process: platelet activation; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; glucose transport; leukocyte migration during inflammatory response; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; platelet degranulation; positive regulation of cell division; defense response to bacterium; immune response; blood coagulation; inflammatory response
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Product Notes
The NAP-2 ppbp (Catalog #AAA553110) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MSLRLDTTPS CNSARPLHAL QVLLLLSLLL TALASSTKGQ TKRNLAKGKE ESLDSDLYAE LRCMCIKTTS GIHPKNIQSL EVIGKGTHCN QVEVIATLKD GRKICLDPDA PRIKKIVQKK LAGDESAD. It is sometimes possible for the material contained within the vial of "NAP-2 (CXCL7), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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