PPAP2A / Lipid Phosphate Phosphohydrolase 1 Recombinant Protein | PPAP2A recombinant protein

Human PPAP2A / Lipid Phosphate Phosphohydrolase 1 Recombinant Protein

Gene Names

PLPP1; LPP1; PAP2; LLP1a; PAP-2a; PPAP2A

Applications

ELISA, Western Blot

Purity

>95% by SDS-PAGE

Synonyms

PPAP2A / Lipid Phosphate Phosphohydrolase 1; Human PPAP2A / Lipid Phosphate Phosphohydrolase 1 Recombinant Protein; Lipid phosphate phosphohydrolase 1; PAP2-alpha; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; PAP-2a; PAP2a; LPP1; PPAP2A recombinant protein

Ordering

Host

E Coli

Purity/Purification

>95% by SDS-PAGE

Form/Format

Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)

Concentration

Reconstitution Dependent (varies by lot)

Sequence Length

284

Applicable Applications for PPAP2A recombinant protein

ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array

Species

Human

Tag

His

Subunit

Homodimer.

Entry Function

Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.

Preparation and Storage

Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

NCBI GI #

45477007

NCBI GeneID

8611

UniProt Accession #

O14494

NCBI Official Full Name

Phospholipid phosphatase 1

NCBI Official Synonym Full Names

phospholipid phosphatase 1

NCBI Official Symbol

PLPP1

NCBI Official Synonym Symbols

LPP1; PAP2; LLP1a; PAP-2a; PPAP2A

NCBI Protein Information

phospholipid phosphatase 1

UniProt Protein Name

Lipid phosphate phosphohydrolase 1

UniProt Gene Name

PPAP2A

UniProt Synonym Gene Names

LPP1; PAP-2a; PAP2a

UniProt Entry Name

LPP1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Uniprot Description

PPAP2A: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. Belongs to the PA-phosphatase related phosphoesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Lipid Metabolism - sphingolipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Membrane protein, multi-pass; Lipid Metabolism - glycerolipid; Phosphatase (non-protein); EC 3.1.3.4

Chromosomal Location of Human Ortholog: 5q11

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: phosphatidate phosphatase activity

Biological Process: steroid hormone receptor signaling pathway; negative regulation of cell proliferation; regulation of lipid metabolic process; sphingolipid metabolic process; sphingolipid biosynthetic process; germ cell migration; protein kinase C activation; androgen receptor signaling pathway; lipid metabolic process; protein amino acid dephosphorylation; phospholipid dephosphorylation

Research Articles on PPAP2A

1. the first of the two transmembrane regions in human SAC1 (TM1) functions in Golgi localization

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Product Notes

The PPAP2A ppap2a (Catalog #AAA2903669) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PPAP2A / Lipid Phosphate Phosphohydrolase 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array. Researchers should empirically determine the suitability of the PPAP2A ppap2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPAP2A / Lipid Phosphate Phosphohydrolase 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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