MRP1 positive control
MRP1 Positive Control
Mediates export of organic anions and drugs from the cytoplasm.
NCBI and Uniprot Product Information
NCBI Description
ATP-binding cassette (ABC) multiple drug resistance protein involved in the release of glutathione synthase during oxidative stress [RGD, Feb 2006]
Uniprot Description
ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported.
Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, ABC family
Cellular Component: basolateral plasma membrane; cytoplasm; integral to plasma membrane; membrane; plasma membrane
Molecular Function: ATP binding; ATPase activity; drug transporter activity; efflux transmembrane transporter activity; glutathione S-conjugate-exporting ATPase activity; lipid-transporting ATPase activity; long-chain fatty acid transporter activity; oxidoreductase activity; sphingolipid transporter activity; xenobiotic-transporting ATPase activity
Biological Process: daunorubicin transport; drug export; multidrug transport; phospholipid efflux; plasma membrane long-chain fatty acid transport; positive regulation of cell migration; response to drug; response to oxidative stress; transmembrane transport; xenobiotic transport
Research Articles on MRP1
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Product Notes
The MRP1 abcc1 (Catalog #AAA542963) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's MRP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the MRP1 abcc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MRP1, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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