GCN2 positive control
GCN2 Positive Control
Can phosphorylate alpha subunit of EIF2 and mediates translational control.
NCBI and Uniprot Product Information
Uniprot Description
GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress.
Protein type: Protein kinase, Other; EC 2.7.11.1; Translation; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; PEK family; GCN2 subfamily
Cellular Component: cytoplasm; intracellular; polysome
Molecular Function: ATP binding; eukaryotic translation initiation factor 2alpha kinase activity; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; RNA binding; transferase activity; tRNA binding
Biological Process: adaptive immune response; cell cycle; cell cycle arrest; cell differentiation; cellular response to amino acid starvation; cellular response to starvation; defense response to virus; immune system process; inhibition of CREB transcription factor; learning; long-term memory; negative regulation of neuron differentiation; negative regulation of translation; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; nervous system development; phosphorylation; positive regulation of adaptive immune response; positive regulation of defense response to virus by host; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translation; regulation of translation initiation in response to stress; regulation of translational initiation; T cell activation during immune response; unfolded protein response; viral protein biosynthetic process; viral reproduction
Research Articles on GCN2
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Product Notes
The GCN2 eif2ak4 (Catalog #AAA542794) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's GCN2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500. Researchers should empirically determine the suitability of the GCN2 eif2ak4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GCN2, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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