Rabbit ZP2 Polyclonal Antibody | anti-ZP2 antibody

ZP2 Rabbit pAb

Cat. Num. AAA8547772

• Gene Names: ZP2; ZPA; Zp-2; OOMD6
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified
• Synonyms: ZP2; Polyclonal Antibody; ZP2 Rabbit pAb; ZPA; Zp-2; anti-ZP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
• Sequence Length: 736

• Applicable Applications for anti-ZP2 antibody: Western Blot (WB)
• Application Notes: WB: 1:1000-1:4000
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 651-745 of human ZP2 (NP_003451.1).
• Cellular Localization: Cell Membrane, Extracellular Matrix, Membrane, Secreted
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-ZP2 antibody

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.

NCBI and Uniprot Product Information

• NCBI GI #: 588282802
• NCBI GeneID: 7783
• NCBI Accession #: NP_001277033.1
• NCBI GenBank Nucleotide #: NP_001277033.1
• UniProt Accession #: Q05996
• Molecular Weight: 68kDa
• NCBI Official Full Name: zona pellucida sperm-binding protein 2 isoform 2 preproprotein
• NCBI Official Synonym Full Names: zona pellucida glycoprotein 2
• NCBI Official Symbol: ZP2
• NCBI Official Synonym Symbols: ZPA; Zp-2; OOMD6
• NCBI Protein Information: zona pellucida sperm-binding protein 2
• UniProt Protein Name: Zona pellucida sperm-binding protein 2
• Protein Family: Zona pellucida sperm-binding protein
• UniProt Gene Name: ZP2
• UniProt Synonym Gene Names: ZPA; Zp-2
• UniProt Entry Name: ZP2_HUMAN

NCBI Description

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed of three glycoproteins with various functions during fertilization and preimplantation development. The glycosylated mature peptide is one of the structural components of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. Female mice lacking this gene do not form a stable zona matrix and are sterile. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Description

ZP2: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Belongs to the ZP domain family. ZPA subfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p12

Cellular Component: endoplasmic reticulum; extracellular matrix; extracellular region; Golgi apparatus; integral to membrane; multivesicular body; plasma membrane; proteinaceous extracellular matrix; secretory granule

Molecular Function: acrosin binding; coreceptor activity

Biological Process: binding of sperm to zona pellucida; intracellular protein transport; manganese ion transport; regulation of acrosome reaction; signal transduction