Western Blot (WB)
((1ug/ml) staining of Human Breast cancer lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat ZNF703 Polyclonal Antibody | anti-ZNF703 antibody
Goat anti-ZNF703 Antibody
Western Blot: Approx 60kDa band observed in Human Breast cancer lysates (calculated MW of 58.2kDa according to NP_079345.1). Recommended concentration: 1-3ug/ml.
Western Blot (WB)
((1ug/ml) staining of Human Breast cancer lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((1ug/ml) staining of Human Breast cancer lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
Uniprot Description
ZNF703: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development. Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation. Belongs to the Elbow/Noc family.
Protein type: C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 8p11.23
Cellular Component: cytoplasm; nuclear matrix; nucleus; protein complex
Molecular Function: metal ion binding; nucleic acid binding; protein binding
Biological Process: negative regulation of homotypic cell-cell adhesion; negative regulation of transcription, DNA-dependent; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of mammary gland epithelial cell proliferation; regulation of cell cycle; regulation of transcription, DNA-dependent; regulation of transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent
Research Articles on ZNF703
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Product Notes
The ZNF703 znf703 (Catalog #AAA421116) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-ZNF703 Antibody reacts with Tested: Human; Expected from sequence similarity: Human, Dog, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's ZNF703 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 60kDa band observed in Human Breast cancer lysates (calculated MW of 58.2kDa according to NP_079345.1). Recommended concentration: 1-3ug/ml. Researchers should empirically determine the suitability of the ZNF703 znf703 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: ELDKKDQEPK PSPE. It is sometimes possible for the material contained within the vial of "ZNF703, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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