Rabbit anti-Human ZNF384 Polyclonal Antibody | anti-ZNF384 antibody

ZNF384, CT (ZNF384, CAGH1, CIZ, NMP4, TNRC1, Zinc finger protein 384, CAG repeat protein 1, CAS-interacting zinc finger protein, Nuclear matrix transcription factor 4, Trinucleotide repeat-containing gene 1 protein)

Cat. Num. AAA6007532

• Gene Names: ZNF384; NP; CIZ; NMP4; CAGH1; ERDA2; TNRC1; CAGH1A
• Reactivity: Human
• Applications: ELISA, Western Blot, Flow Cytometry, Functional Assay
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: ZNF384; Polyclonal Antibody; CT (ZNF384; CAGH1; CIZ; NMP4; TNRC1; Zinc finger protein 384; CAG repeat protein 1; CAS-interacting zinc finger protein; Nuclear matrix transcription factor 4; Trinucleotide repeat-containing gene 1 protein); Anti -ZNF384; anti-ZNF384 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-ZNF384 antibody: ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
• Application Notes: Suitable for use in Western Blot, Flow Cytometry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500; Flow Cytometry: 1:10-50
• Immunogen: ZNF384 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 538-567 amino acids from the C-terminal region of human ZNF384.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(ZNF384 Antibody (C-term) western blot analysis in MCF-7,Hela cell line lysates (35ug/lane).This demonstrates the ZNF384 antibody detected the ZNF384 protein (arrow).)

Flow Cytometry (FC/FACS)

(ZNF384 Antibody (C-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-ZNF384 antibody

This gene contains long CAG trinucleotide repeats coding consecutive glutamine residues. The gene product may functions as a transcription factor, with a potential role in the regulation of neurodevelopment or neuroplasticity. The protein appears to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Multiple transcript variants encoding several isoforms have been found for this gene.

Product Categories/Family for anti-ZNF384 antibody

Antibodies; Abs to Transcription Factors; Zinc (Ring) Finger

NCBI and Uniprot Product Information

• NCBI GI #: 209180475
• NCBI GeneID: 171017
• NCBI Accession #: NP_001129206.1
• NCBI GenBank Nucleotide #: NM_001135734.2
• UniProt Accession #: Q8TF68; O15407; Q7Z722; Q8N938
• Molecular Weight: 63,219 Da
• NCBI Official Full Name: zinc finger protein 384 isoform d
• NCBI Official Synonym Full Names: zinc finger protein 384
• NCBI Official Symbol: ZNF384
• NCBI Official Synonym Symbols: NP; CIZ; NMP4; CAGH1; ERDA2; TNRC1; CAGH1A
• NCBI Protein Information: zinc finger protein 384; CAG repeat protein 1; expanded repeat domain, CAG/CTG 2; Cas-interacting zinc finger protein; nuclear matrix transcription factor 4; trinucleotide repeat-containing gene 1 protein
• UniProt Protein Name: Zinc finger protein 384
• Protein Family: Zinc finger protein
• UniProt Gene Name: ZNF384
• UniProt Synonym Gene Names: CAGH1; CIZ; NMP4; TNRC1; Nuclear matrix protein 4
• UniProt Entry Name: ZN384_HUMAN

NCBI Description

This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]

Uniprot Description

ZNF384: Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1. Belongs to the krueppel C2H2-type zinc-finger protein family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: focal adhesion; nucleus

Molecular Function: sequence-specific DNA binding; metal ion binding; SH3 domain binding

Biological Process: positive regulation of protein secretion; transcription, DNA-dependent; nucleocytoplasmic transport; positive regulation of transcription from RNA polymerase II promoter