Western Blot (WB)
(Western blot analysis of ZIC1/2/3/4/5 expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates.)
Rabbit ZIC1/2/3/4/5 Polyclonal Antibody | anti-ZIC1 antibody
Anti-ZIC1/2/3/4/5 Antibody
Western Blot (WB)
(Western blot analysis of ZIC1/2/3/4/5 expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of ZIC1/2/3/4/5 expression in HEK293T (A), Raw264.7 (B), H9C2 (C) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ZIC1: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3'. Belongs to the GLI C2H2-type zinc-finger protein family.
Protein type: Transcription factor; C2H2-type zinc finger protein; DNA-binding
Chromosomal Location of Human Ortholog: 3q24
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: DNA binding; metal ion binding; transcription factor activity
Biological Process: inner ear morphogenesis; transcription, DNA-dependent; positive regulation of protein import into nucleus; spinal cord development; positive regulation of transcription, DNA-dependent; brain development; cell differentiation; adult walking behavior; pattern specification process; regulation of smoothened signaling pathway
Research Articles on ZIC1
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Product Notes
The ZIC1 zic1 (Catalog #AAA8237040) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ZIC1/2/3/4/5 Antibody reacts with Human, Mouse, Rat, Chicken and may cross-react with other species as described in the data sheet. AAA Biotech's ZIC1/2/3/4/5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1/500 - 1/1000). Researchers should empirically determine the suitability of the ZIC1 zic1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ZIC1/2/3/4/5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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