Western Blot (WB)
(Western Blot analysis of extracts of HeLa cell line, using XPO1 antibody.)
Rabbit anti-Human, Mouse XPO1 Polyclonal Antibody | anti-XPO1 antibody
XPO1 Polyclonal Antibody
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot analysis of extracts of HeLa cell line, using XPO1 antibody.)
Western Blot (WB)
(Western Blot analysis of extracts of HeLa cell line, using XPO1 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]
Uniprot Description
Exportin-1: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of an nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. Belongs to the exportin family.
Protein type: Karyopherin; Nuclear import; Nucleolus; Nuclear export
Chromosomal Location of Human Ortholog: 2p15
Cellular Component: kinetochore; nucleoplasm; Cajal body; nuclear membrane; intracellular membrane-bound organelle; membrane; cytoplasm; nucleolus; nuclear envelope; cytosol; ribonucleoprotein complex; nucleus; annulate lamellae
Molecular Function: protein domain specific binding; protein binding; RNA binding; transporter activity; Ran GTPase binding; protein transporter activity; nucleocytoplasmic transporter activity
Biological Process: response to drug; ribosomal small subunit export from nucleus; mRNA transport; viral reproduction; transforming growth factor beta receptor signaling pathway; regulation of protein catabolic process; gene expression; viral infectious cycle; negative regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; protein export from nucleus; negative regulation of transforming growth factor beta receptor signaling pathway; ribosomal large subunit export from nucleus; regulation of protein export from nucleus
Research Articles on XPO1
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Product Notes
The XPO1 xpo1 (Catalog #AAA3008364) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The XPO1 Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's XPO1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the XPO1 xpo1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "XPO1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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