Rabbit anti-Human WRAP53 Polyclonal Antibody | anti-WRAP53 antibody

WRAP53 (WD40 Repeat-containing Protein Encoding RNA Antisense to p53, Telomerase Cajal Body Protein 1, TCAB1, WD Repeat-containing Protein 79, WDR79, DKCB3) APC

Cat. Num. AAA6398536

• Gene Names: WRAP53; DKCB3; TCAB1; WDR79
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: WRAP53; Polyclonal Antibody; WRAP53 (WD40 Repeat-containing Protein Encoding RNA Antisense to p53; Telomerase Cajal Body Protein 1; TCAB1; WD Repeat-containing Protein 79; WDR79; DKCB3) APC; anti-WRAP53 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human WDR79.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
• Sequence Length: 1757

• Applicable Applications for anti-WRAP53 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human WDR79, aa1-548 (AAH02336.1).
• Immunogen Sequence: MKTLETQPLAPDCCPSDQDPAPAHPSPHASPMNKNADSELMPPPPERGDPPRLSPDPVAGSAVSQELREGDPVSLSTPLETEFGSPSELSPRIEEQELSENTSLPAEEANGSLSEEEANGPELGSGKAMEDTSGEPAAEDEGDTAWNYSFSQLPRFLSGSWSEFSTQPENFLKGCKWAPDGSCILTNSADNILRIYNLPPELYHEGEQVEYAEMVPVLRMVEGDTIYDYCWYSLMSSAQPDTSYVASSSRENPIHIWDAFTGELRASFRAYNHLDELTAAHSLCFSPDGSQLFCGFNRTVRVFSTARPGRDCEVRATFAKKQGQSGIISCIAFSPAQPLYACGSYGRSLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNRFFSGARKDAELLCWDLRQSGYPLWSLGREVTTNQRIYFDLDPTGQFLVSGSTSGAVSVWDTDGPGNDGKPEPVLSFLPQKDCTNGVSLHPSLPLLATASGQRVFPEPTESGDEGEELGLPLLSTRHVHLECRLQLWWCGGAPDSSIPDDHQGEKGQGGTEGGVGELI
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(WDR79 rabbit polyclonal antibody. Western Blot analysis of WDR79 expression in HepG2.)

Western Blot (WB)

(Western Blot analysis of WDR79 expression in transfected 293T cell line by WDR79 polyclonal antibody. Lane 1: WDR79 transfected lysate (59.3kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-WRAP53 antibody

Antibodies; WD Repeat Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 33990682
• NCBI GeneID: 55135
• NCBI Official Full Name: Homo sapiens WD repeat containing, antisense to TP53, mRNA
• NCBI Official Synonym Full Names: WD repeat containing antisense to TP53
• NCBI Official Symbol: WRAP53
• NCBI Official Synonym Symbols: DKCB3; TCAB1; WDR79
• NCBI Protein Information: telomerase Cajal body protein 1
• Protein Family: Telomerase Cajal body protein

NCBI Description

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]