Rabbit anti-Human WFDC1 Polyclonal Antibody | anti-WFDC1 antibody

WFDC1 Antibody

Cat. Num. AAA9413725

• Gene Names: WFDC1; PS20
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: WFDC1; Polyclonal Antibody; WFDC1 Antibody; PS20; anti-WFDC1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total WFDC1 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 2.2 mg/ml (varies by lot)
• Sequence Length: 220

• Applicable Applications for anti-WFDC1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide of human WAP four-disulfide core domain 1
• Target Name: WFDC1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/35.)

Related Product Information for anti-WFDC1 antibody

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants.

Product Categories/Family for anti-WFDC1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 541862107
• NCBI GeneID: 58189
• NCBI Accession #: NP_001269395.1
• NCBI GenBank Nucleotide #: NM_001282466.1
• UniProt Accession #: Q9HC57; Q8NC27; Q9HAU1; D3DUL7
• Molecular Weight: 23,977 Da
• NCBI Official Full Name: WAP four-disulfide core domain protein 1 isoform 1
• NCBI Official Synonym Full Names: WAP four-disulfide core domain 1
• NCBI Official Symbol: WFDC1
• NCBI Official Synonym Symbols: PS20
• NCBI Protein Information: WAP four-disulfide core domain protein 1
• UniProt Protein Name: WAP four-disulfide core domain protein 1
• Protein Family: WAP four-disulfide core domain protein
• UniProt Gene Name: WFDC1
• UniProt Synonym Gene Names: PS20
• UniProt Entry Name: WFDC1_HUMAN

NCBI Description

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

WFDC1: Has growth inhibitory activity.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: response to drug; negative regulation of cell growth; response to estradiol stimulus; negative regulation of epithelial cell proliferation