Rabbit WDR73 Polyclonal Antibody | anti-WDR73 antibody

WDR73 Antibody

Cat. Num. AAA9630230

• Gene Names: WDR73; HSPC264
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: WDR73; Polyclonal Antibody; WDR73 Antibody; 1200011I23Rik; 2410008B13Rik; AI848574; C85352; FLJ00296 protein; FLJ14888; HSPC264; Neuromedin B; Nmb; OTTMUSP00000029485; OTTMUSP00000029486; WD repeat containing protein 73; WD repeat domain 73; WDR 73; anti-WDR73 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: WDR73 Antibody detects endogenous levels of WDR73.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-WDR73 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human WDR73.
• Conjugation: Unconjugated
• Similarity: Belongs to the WD repeat WDR73 family.
• Tissue Specificity: Expressed in kidney and brain. In the kidney, expressed in glomeruli, most probably in podocytes, and in tubules (at protein level). In the brain, expressed in the cerebellum, with high levels in Purkinje cells and their projecting axons, in the deep cerebellar nuclei and in pyramidal neurons of the cerebral cortex (at protein level). In the white matter, mainly present in astrocytes, but not in oligodendrocytes (at protein level). Also highly expressed in endothelial cells of cerebral capillaries (at protein level).
• Function: May play a role in the regulation of microtubule organization and dynamics.
• Note: During interphase, located in the cytosol. During mitosis, accumulates at the spindle poles and microtubule asters and later in the cleavage furrow.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-WDR73 antibody

Cytoplasm; Cytosol; Cytoskeleton; Spindle; Spindle pole; Cleavage furrow; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 55930876
• NCBI GeneID: 84942
• UniProt Accession #: Q6P4I2; Q96JZ1; Q9P0B7
• Molecular Weight: 41,685 Da
• NCBI Official Full Name: WDR73 protein, partial
• NCBI Official Synonym Full Names: WD repeat domain 73
• NCBI Official Symbol: WDR73
• NCBI Official Synonym Symbols: HSPC264
• NCBI Protein Information: WD repeat-containing protein 73; FLJ00296 protein
• UniProt Protein Name: WD repeat-containing protein 73
• Protein Family: WD repeat-containing protein
• UniProt Gene Name: WDR73
• UniProt Entry Name: WDR73_HUMAN

NCBI Description

The protein encoded by this gene is thought to contain multiple WD40 repeats. WD40 repeats are motifs that contain 40-60 amino acids, and usually end with Trp-Asp (WD). This protein is found in the cytoplasm during interphase, but accumulates at the spindle poles and astral microtubules during mitosis. Reduced expression of this gene results in abnormalities in the size and morphology of the nucleus. Mutations in this gene have been associated with Galloway-Mowat syndrome PMID: 25466283), which is a rare autosomal recessive disorder that affects both the central nervous system and kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Description

WDR73: Belongs to the WD repeat WDR73 family.

Chromosomal Location of Human Ortholog: 15q25.2

Disease: Galloway-mowat Syndrome