Immunohistochemistry (IHC)
(Immunochemical staining of human WDR1 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human WDR1 Polyclonal Antibody | anti-WDR1 antibody
Anti-WDR1 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
WDR1; Polyclonal Antibody; Anti-WDR1 Antibody; Rabbit Polyclonal; WDR1 Antibody; Rabbit PAb; Antigen Affinity Purified; WD repeat domain 1; Anti-AIP1 Antibody; Anti-HEL-S-52 Antibody; Anti-NORI-1 Antibody; anti-WDR1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human WDR1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-WDR1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human WDR1 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human WDR1 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human WDR1 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human WDR1 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-WDR1 antibody
Actin-depolymerizing factor (ADF)/cofilin and actin-interacting protein 1 (AIP1), also known as WD-repeat protein 1 (WDR1), is conserved among eukaryotes and play critical roles in the dynamic reorganization of the actin cytoskeleton. AIP1 preferentially promotes disassembly of ADF/cofilin-decorated actin filaments but exhibits minimal effects on bare actin filaments. Therefore, AIP1 has been often considered to be an ancillary co-factor of ADF/cofilin that merely boosts ADF/cofilin activity level. Several studies have found that WDR1 is dysregulated in several types of cancer and is associated with cancer metastasis. WDR1 could be used as a new useful prognostic marker and may be a potential therapeutic target for hepatocellular carcinoma (HCC). The ADF/cofilin-WDR1-actin axis as an activator of the malignant phenotype will be a promising therapeutic target in lung cancer.
References
Zheng L, et al. (2018) Wdr1 predicts poor prognosis and promotes cancer progression in hepatocellular carcinoma. Int J Clin Exp Pathol 11 (12): 5682-5693.Yuan B, et al. (2018) Wdr1 promotes cell growth and migration and contributes to malignant phenotypes of non-small cell lung cancer through adf/cofilin-mediated actin dynamics. Int J Biol Sci 14 (9): 1067-1080.Ono S (2018) Functions of actin-interacting protein 1 (aip1)/wd repeat protein 1 (wdr1) in actin filament dynamics and cytoskeletal regulation. Biochem Biophys Res Commun 506 (2): 315-322.Huang X, et al. (2019) Knockout of wdr1 results in cardiac hypertrophy and impaired cardiac function in adult mouse heart. Gene 697 40-47.
Similar Products
Product Notes
The WDR1 (Catalog #AAA8109686) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-WDR1 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's WDR1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the WDR1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "WDR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
